dc.contributor.author |
Winnubst, J |
en |
dc.contributor.author |
Cheyne, Juliette |
en |
dc.contributor.author |
Niculescu, D |
en |
dc.contributor.author |
Lohmann, C |
en |
dc.date.accessioned |
2017-09-22T03:41:12Z |
en |
dc.date.issued |
2015-07 |
en |
dc.identifier.citation |
Neuron 87(2):399-410 Jul 2015 |
en |
dc.identifier.issn |
0896-6273 |
en |
dc.identifier.uri |
http://hdl.handle.net/2292/35748 |
en |
dc.description.abstract |
Spontaneous activity fine-tunes neuronal connections in the developing brain. To explore the underlying synaptic plasticity mechanisms, we monitored naturally occurring changes in spontaneous activity at individual synapses with whole-cell patch-clamp recordings and simultaneous calcium imaging in the mouse visual cortex in vivo. Analyzing activity changes across large populations of synapses revealed a simple and efficient local plasticity rule: synapses that exhibit low synchronicity with nearby neighbors (<12 μm) become depressed in their transmission frequency. Asynchronous electrical stimulation of individual synapses in hippocampal slices showed that this is due to a decrease in synaptic transmission efficiency. Accordingly, experimentally increasing local synchronicity, by stimulating synapses in response to spontaneous activity at neighboring synapses, stabilized synaptic transmission. Finally, blockade of the high-affinity proBDNF receptor p75(NTR) prevented the depression of asynchronously stimulated synapses. Thus, spontaneous activity drives local synaptic plasticity at individual synapses in an "out-of-sync, lose-your-link" fashion through proBDNF/p75(NTR) signaling to refine neuronal connectivity. |
en |
dc.format.medium |
Print |
en |
dc.language |
eng |
en |
dc.publisher |
Elsevier |
en |
dc.relation.ispartofseries |
Neuron |
en |
dc.rights |
Items in ResearchSpace are protected by copyright, with all rights reserved, unless otherwise indicated. Previously published items are made available in accordance with the copyright policy of the publisher. |
en |
dc.rights.uri |
https://researchspace.auckland.ac.nz/docs/uoa-docs/rights.htm |
en |
dc.subject |
Visual Cortex |
en |
dc.subject |
Nerve Net |
en |
dc.subject |
Neurons |
en |
dc.subject |
Animals |
en |
dc.subject |
Mice, Inbred C57BL |
en |
dc.subject |
Animals, Newborn |
en |
dc.subject |
Mice, Transgenic |
en |
dc.subject |
Mice |
en |
dc.subject |
Calcium |
en |
dc.subject |
Quinoxalines |
en |
dc.subject |
Luminescent Proteins |
en |
dc.subject |
Excitatory Amino Acid Antagonists |
en |
dc.subject |
Organ Culture Techniques |
en |
dc.subject |
Patch-Clamp Techniques |
en |
dc.subject |
Electric Stimulation |
en |
dc.subject |
Signal Transduction |
en |
dc.subject |
Action Potentials |
en |
dc.subject |
Neuronal Plasticity |
en |
dc.subject |
Models, Biological |
en |
dc.subject |
Computer Simulation |
en |
dc.subject |
In Vitro Techniques |
en |
dc.title |
Spontaneous activity drives local synaptic plasticity in vivo |
en |
dc.type |
Journal Article |
en |
dc.identifier.doi |
10.1016/j.neuron.2015.06.029 |
en |
pubs.issue |
2 |
en |
pubs.begin-page |
399 |
en |
pubs.volume |
87 |
en |
dc.rights.holder |
Copyright: Elsevier |
en |
dc.identifier.pmid |
26182421 |
en |
pubs.end-page |
410 |
en |
pubs.publication-status |
Published |
en |
dc.rights.accessrights |
http://purl.org/eprint/accessRights/RestrictedAccess |
en |
pubs.subtype |
Article |
en |
pubs.elements-id |
546555 |
en |
pubs.org-id |
Medical and Health Sciences |
en |
pubs.org-id |
Medical Sciences |
en |
pubs.org-id |
Physiology Division |
en |
dc.identifier.eissn |
1097-4199 |
en |
pubs.record-created-at-source-date |
2017-09-22 |
en |
pubs.dimensions-id |
26182421 |
en |