Renal denervation in male rats with heart failure improves ventricular sympathetic nerve innervation and function

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dc.contributor.author Pinkham, MI en
dc.contributor.author Loftus, MT en
dc.contributor.author Amirapu, Satya en
dc.contributor.author Guild, Sarah-Jane en
dc.contributor.author Quill, G en
dc.contributor.author Woodward, WR en
dc.contributor.author Habecker, BA en
dc.contributor.author Barrett, Carolyn en
dc.date.accessioned 2017-09-24T21:09:51Z en
dc.date.issued 2017-03 en
dc.identifier.citation American Journal of Physiology - Regulatory Integrative and Comparative Physiology 312(3):R368-R379 Mar 2017 en
dc.identifier.issn 0363-6119 en
dc.identifier.uri http://hdl.handle.net/2292/35755 en
dc.description.abstract Heart failure is characterized by the loss of sympathetic innervation to the ventricles, contributing to impaired cardiac function and arrhythmogenesis. We hypothesized that renal denervation (RDx) would reverse this loss. Male Wistar rats underwent myocardial infarction (MI) or sham surgery and progressed into heart failure for 4 wk before receiving bilateral RDx or sham RDx. After additional 3 wk, left ventricular (LV) function was assessed, and ventricular sympathetic nerve fiber density was determined via histology. Post-MI heart failure rats displayed significant reductions in ventricular sympathetic innervation and tissue norepinephrine content (nerve fiber density in the LV of MI+sham RDx hearts was 0.31 ± 0.05% vs. 1.00 ± 0.10% in sham MI+sham RDx group, P < 0.05), and RDx significantly increased ventricular sympathetic innervation (0.76 ± 0.14%, P < 0.05) and tissue norepinephrine content. MI was associated with an increase in fibrosis of the noninfarcted ventricular myocardium, which was attenuated by RDx. RDx improved LV ejection fraction and end-systolic and -diastolic areas when compared with pre-RDx levels. This is the first study to show an interaction between renal nerve activity and cardiac sympathetic nerve innervation in heart failure. Our findings show denervating the renal nerves improves cardiac sympathetic innervation and function in the post-MI failing heart. en
dc.format.medium Print-Electronic en
dc.language eng en
dc.publisher American Physiological Society en
dc.relation.ispartofseries American Journal of Physiology - Regulatory Integrative and Comparative Physiology en
dc.rights Items in ResearchSpace are protected by copyright, with all rights reserved, unless otherwise indicated. Previously published items are made available in accordance with the copyright policy of the publisher. en
dc.rights.uri https://researchspace.auckland.ac.nz/docs/uoa-docs/rights.htm en
dc.subject Kidney en
dc.subject Heart Ventricles en
dc.subject Animals en
dc.subject Rats en
dc.subject Rats, Wistar en
dc.subject Ventricular Dysfunction, Left en
dc.subject Stroke Volume en
dc.subject Treatment Outcome en
dc.subject Sympathectomy en
dc.subject Male en
dc.subject Heart Failure en
dc.title Renal denervation in male rats with heart failure improves ventricular sympathetic nerve innervation and function en
dc.type Journal Article en
dc.identifier.doi 10.1152/ajpregu.00313.2016 en
pubs.issue 3 en
pubs.begin-page R368 en
pubs.volume 312 en
dc.rights.holder Copyright: American Physiological Society en
dc.identifier.pmid 28052866 en
pubs.end-page R379 en
pubs.publication-status Published en
dc.rights.accessrights http://purl.org/eprint/accessRights/RestrictedAccess en
pubs.subtype Article en
pubs.elements-id 606796 en
pubs.org-id Medical and Health Sciences en
pubs.org-id Medical Sciences en
pubs.org-id Physiology Division en
dc.identifier.eissn 1522-1490 en
pubs.record-created-at-source-date 2017-09-25 en
pubs.dimensions-id 28052866 en


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