dc.contributor.author |
Wassink, Guido |
en |
dc.contributor.author |
Lear, Christopher |
en |
dc.contributor.author |
Gunn, KC |
en |
dc.contributor.author |
Dean, Justin |
en |
dc.contributor.author |
Bennet, Laura |
en |
dc.contributor.author |
Gunn, Alistair |
en |
dc.date.accessioned |
2017-10-11T20:40:36Z |
en |
dc.date.issued |
2015-04 |
en |
dc.identifier.citation |
Seminars in Fetal and Neonatal Medicine, 20(2):109-114 Apr 2015 |
en |
dc.identifier.issn |
1744-165X |
en |
dc.identifier.uri |
http://hdl.handle.net/2292/35967 |
en |
dc.description.abstract |
Multiple randomized controlled trials have shown that prolonged, moderate cerebral hypothermia initiated within a few hours after severe hypoxia–ischemia and continued until resolution of the acute phase of delayed cell death reduces mortality and improves neurodevelopmental outcome in term infants. The challenge is now to find ways to further improve outcomes. In the present review, we critically examine the evidence that conventional analgesic, sedative, or anticonvulsant agents might improve outcomes, in relation to the known window of opportunity for effective protection with hypothermia. This review strongly indicates that there is insufficient evidence to recommend routine use of these agents during therapeutic hypothermia. Further systematic research into the effects of pain and stress on the injured brain, and their treatment during hypothermia, is essential to guide the rational development of clinical treatment protocols. |
en |
dc.description.uri |
https://www.ncbi.nlm.nih.gov/pubmed/25457080 |
en |
dc.language |
English |
en |
dc.publisher |
Elsevier |
en |
dc.relation.ispartofseries |
Seminars in Fetal and Neonatal Medicine |
en |
dc.rights |
Items in ResearchSpace are protected by copyright, with all rights reserved, unless otherwise indicated. Previously published items are made available in accordance with the copyright policy of the publisher. Details obtained from http://sherpa.ac.uk/romeo/issn/1744-165X/
https://www.elsevier.com/about/our-business/policies/sharing |
en |
dc.rights.uri |
https://researchspace.auckland.ac.nz/docs/uoa-docs/rights.htm |
en |
dc.title |
Analgesics, sedatives, anticonvulsant drugs, and the cooled brain |
en |
dc.type |
Journal Article |
en |
dc.identifier.doi |
10.1016/j.siny.2014.10.003 |
en |
pubs.issue |
2 |
en |
pubs.begin-page |
109 |
en |
pubs.volume |
20 |
en |
dc.rights.holder |
Copyright: Elsevier |
en |
dc.identifier.pmid |
25457080 |
en |
pubs.author-url |
http://www.sciencedirect.com/science/article/pii/S1744165X1400081X |
en |
pubs.end-page |
114 |
en |
pubs.publication-status |
Published |
en |
dc.rights.accessrights |
http://purl.org/eprint/accessRights/RestrictedAccess |
en |
pubs.subtype |
Article |
en |
pubs.subtype |
Review |
en |
pubs.elements-id |
467313 |
en |
pubs.org-id |
Medical and Health Sciences |
en |
pubs.org-id |
Medical Sciences |
en |
pubs.org-id |
Physiology Division |
en |
dc.identifier.eissn |
1878-0946 |
en |
pubs.record-created-at-source-date |
2014-12-07 |
en |
pubs.online-publication-date |
2014-11-01 |
en |
pubs.dimensions-id |
25457080 |
en |