Does maturity effect cephalic perfusion and T/QRS ratio during prolonged umbilical cord occlusion in fetal sheep?

Show simple item record Wassink, Guido en Galinsky, Robert en Drury, Paul en Gunn, Eleanor en Bennet, Laura en Gunn, Alistair en
dc.coverage.spatial United States en 2017-10-12T23:32:55Z en 2014 en
dc.identifier.citation Obstetrics and Gynecology International, 2014:314159, 2014 en
dc.identifier.issn 1687-9589 en
dc.identifier.uri en
dc.description.abstract T/QRS ratio monitoring is used to help identify fetal asphyxia. However, immature animals have greater capacity to maintain blood pressure during severe asphyxia, raising the possibility that they may show an attenuated T/QRS increase during asphyxia. Chronically instrumented fetal sheep at 0.6 of gestation (0.6 GA; n = 12), 0.7 GA (n = 12), and 0.8 GA (n = 8) underwent complete umbilical cord occlusion for 30 min, 25 min, or 15 min, respectively. Cord occlusion was associated with progressive metabolic acidosis and initial hypertension followed by severe hypotension, with a more rapid fall in mean arterial blood pressure (MAP) and carotid blood flow (CaBF) with advancing gestation. T/QRS ratio rose after occlusion more rapidly at 0.8 GA than in immature fetuses, to a similar final peak at all ages, followed by a progressive fall that was slower at 0.8 GA than in the immature fetuses. The increase in T/QRS ratio correlated with initial hypertension at 0.8 GA (P < 0.05, R (2) = 0.38), and conversely, its fall correlated closely with falling MAP in all gestational groups (P < 0.01, R (2) = 0.67). In conclusion, elevation of the T/QRS ratio is an index of onset of severe asphyxia in the last third of gestation, but not of fetal compromise. en
dc.description.uri en
dc.language eng en
dc.publisher Hindawi Publishing Corporation en
dc.relation.ispartofseries Obstetrics and Gynecology International en
dc.rights Items in ResearchSpace are protected by copyright, with all rights reserved, unless otherwise indicated. Previously published items are made available in accordance with the copyright policy of the publisher. Details obtained from en
dc.rights.uri en
dc.rights.uri en
dc.title Does maturity effect cephalic perfusion and T/QRS ratio during prolonged umbilical cord occlusion in fetal sheep? en
dc.type Journal Article en
dc.identifier.doi 10.1155/2014/314159 en
pubs.volume 2014 en
dc.rights.holder Copyright: The authors en
dc.identifier.pmid 24693290 en en
pubs.publication-status Published en
dc.rights.accessrights en
pubs.subtype Article en
pubs.elements-id 434802 en Medical and Health Sciences en Medical Sciences en Physiology Division en School of Medicine en Paediatrics Child & Youth Hlth en
dc.identifier.eissn 1687-9597 en
pubs.number 314159 en
pubs.record-created-at-source-date 2014-04-15 en
pubs.dimensions-id 24693290 en

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