dc.contributor.author |
Mulder, M |
en |
dc.contributor.author |
Koopmans, G |
en |
dc.contributor.author |
Wassink, Guido |
en |
dc.contributor.author |
Al Mansouri, G |
en |
dc.contributor.author |
Simard, M-L |
en |
dc.contributor.author |
Havekes, LM |
en |
dc.contributor.author |
Prickaerts, J |
en |
dc.contributor.author |
Blokland, A |
en |
dc.date.accessioned |
2017-10-13T04:38:48Z |
en |
dc.date.available |
2007-07-03 |
en |
dc.date.issued |
2007-11 |
en |
dc.identifier.citation |
Neuroscience Research, 59(3):251-256 Nov 2007 |
en |
dc.identifier.issn |
0168-0102 |
en |
dc.identifier.uri |
http://hdl.handle.net/2292/36043 |
en |
dc.description.abstract |
An aberrant cholesterol metabolism in the brain may contribute to the pathogenesis of Alzheimer's disease (AD). The LDL receptor (LDLR) regulates plasma cholesterol levels and recently we and others obtained evidence that it is also involved in regulating brain cholesterol homeostasis. Moreover, we found that LDLR-deficient mice display impaired spatial memory. Because cholesterol, in part derived from cellular uptake via LDLR, is required for peripheral cell proliferation and growth, we examined the effect of absence of the LDLR on hippocampal proliferation and the density of synaptic connections. Mice deficient for the LDLR displayed a reduced number of proliferating (BrdU-labeled) cells in the hippocampus as compared to wild type control mice. In addition, the number of synaptophysin-immunoreactive presynaptic boutons in the hippocampal CA1 and the dentate gyrus (DG) areas, but not in cortical areas, was lower in the LDLR-knockout mice than in the control mice. In vitro experiments showed that LDLR activity is increased when cell growth is enhanced by the addition of N2 supplement. This further supports a role for the LDLR in the outgrowth of neurites. These findings support the notion that, similar to its role in the periphery, the LDLR is important for the cellular uptake of cholesterol in the brain and that disturbance of this process affects neuronal plasticity. |
en |
dc.description.uri |
https://www.ncbi.nlm.nih.gov/pubmed/17720268 |
en |
dc.format.medium |
Print-Electronic |
en |
dc.language |
English |
en |
dc.publisher |
Elsevier |
en |
dc.relation.ispartofseries |
Neuroscience Research |
en |
dc.rights |
Items in ResearchSpace are protected by copyright, with all rights reserved, unless otherwise indicated. Previously published items are made available in accordance with the copyright policy of the publisher. Details obtained from http://sherpa.ac.uk/romeo/issn/0168-0102/
https://www.elsevier.com/about/our-business/policies/sharing |
en |
dc.rights.uri |
https://researchspace.auckland.ac.nz/docs/uoa-docs/rights.htm |
en |
dc.subject |
Hippocampus |
en |
dc.subject |
Dentate Gyrus |
en |
dc.subject |
Neural Pathways |
en |
dc.subject |
Presynaptic Terminals |
en |
dc.subject |
Cell Line, Tumor |
en |
dc.subject |
Animals |
en |
dc.subject |
Mice, Knockout |
en |
dc.subject |
Humans |
en |
dc.subject |
Mice |
en |
dc.subject |
Cholesterol |
en |
dc.subject |
Synaptophysin |
en |
dc.subject |
Receptors, LDL |
en |
dc.subject |
Bromodeoxyuridine |
en |
dc.subject |
Biological Markers |
en |
dc.subject |
Cell Count |
en |
dc.subject |
Cell Proliferation |
en |
dc.subject |
Down-Regulation |
en |
dc.subject |
Neuronal Plasticity |
en |
dc.subject |
Male |
en |
dc.title |
LDL receptor deficiency results in decreased cell proliferation and presynaptic bouton density in the murine hippocampus |
en |
dc.type |
Journal Article |
en |
dc.identifier.doi |
10.1016/j.neures.2007.07.004 |
en |
pubs.issue |
3 |
en |
pubs.begin-page |
251 |
en |
pubs.volume |
59 |
en |
dc.rights.holder |
Copyright: Elsevier |
en |
dc.identifier.pmid |
17720268 |
en |
pubs.author-url |
http://www.sciencedirect.com/science/article/pii/S0168010207016884 |
en |
pubs.end-page |
256 |
en |
pubs.publication-status |
Published |
en |
dc.rights.accessrights |
http://purl.org/eprint/accessRights/RestrictedAccess |
en |
pubs.subtype |
Article |
en |
pubs.elements-id |
616286 |
en |
pubs.org-id |
Medical and Health Sciences |
en |
pubs.org-id |
Medical Sciences |
en |
pubs.org-id |
Physiology Division |
en |
dc.identifier.eissn |
1872-8111 |
en |
pubs.record-created-at-source-date |
2017-10-13 |
en |
pubs.online-publication-date |
2007-07-17 |
en |
pubs.dimensions-id |
17720268 |
en |