Carbimazole-Induced Hepatotoxicity - Avoid Rechallenging

Show simple item record Karalus, M en Tamatea, Jade en Conaglen, John en Elston, Marianne en 2017-10-15T23:02:15Z en 2016 en
dc.identifier.citation JSM Thyroid Disorders and Management 1(1):3 pages 2016 en
dc.identifier.uri en
dc.description.abstract All thioamide anti - thyroid medications are known to be associated with liver dysfunction. Cholestasis is most commonly reported in association with carbimazole/methimazole. We report a patient with Graves’ disease, who developed acute Hepatocellular dysfunction associated with carbimazole. There is limited data available on re -exposure in this situation. The patient rechallenged herself twice and subsequent exposures resulted in an increasingly shorter time to symptom onset until finally even a single 5mg tablet rapidly provoked severe symptoms and abnormal liver function tests. This case supports the need to avoid anti - thyroid medication rechallenge in patients who develop significant liver dysfunction following their use and identifies that carbimazole may be associated with acute Hepatocellular dysfunction and not just Cholestasis. en
dc.relation.ispartofseries JSM Thyroid Disorders and Management en
dc.rights Items in ResearchSpace are protected by copyright, with all rights reserved, unless otherwise indicated. Previously published items are made available in accordance with the copyright policy of the publisher. Details obtained from en
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dc.title Carbimazole-Induced Hepatotoxicity - Avoid Rechallenging en
dc.type Journal Article en
pubs.issue 1 en
pubs.volume 1 en
dc.description.version VoR - Version of Record en
dc.rights.holder Copyright: The author en
dc.rights.accessrights en
pubs.subtype Article en
pubs.elements-id 608151 en Medical and Health Sciences en School of Medicine en Medicine Department en Te Kupenga Hauora Maori en TKHM Teaching en
pubs.record-created-at-source-date 2017-01-18 en 2016 en

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