Novel Adociaquinone Derivatives from the Indonesian Sponge Xestospongia sp.

He, F; Mai, LH; Longeon, A; Copp, Brent; Loaëc, N; Bescond, A; Meijer, L; Bourguet-Kondracki, M-L

dc.contributor.author	He, F	en
dc.contributor.author	Mai, LH	en
dc.contributor.author	Longeon, A	en
dc.contributor.author	Copp, Brent	en
dc.contributor.author	Loaëc, N	en
dc.contributor.author	Bescond, A	en
dc.contributor.author	Meijer, L	en
dc.contributor.author	Bourguet-Kondracki, M-L	en
dc.date.accessioned	2017-10-16T01:18:32Z	en
dc.date.available	2015-04-03	en
dc.date.issued	2015-04-28	en
dc.identifier.citation	Marine Drugs, 13(5):2617-2628, 28 Apr 2015	en
dc.identifier.issn	1660-3397	en
dc.identifier.uri	http://hdl.handle.net/2292/36069	en
dc.description.abstract	Seven new adociaquinone derivatives, xestoadociaquinones A (1a), B (1b), 14-carboxy-xestoquinol sulfate (2) and xestoadociaminals A-D (3a, 3c, 4a, 4c), together with seven known compounds (5-11) were isolated from an Indonesian marine sponge Xestospongia sp. Their structures were elucidated by extensive 1D and 2D NMR and mass spectrometric data. All the compounds were evaluated for their potential inhibitory activity against eight different protein kinases involved in cell proliferation, cancer, diabetes and neurodegenerative disorders as well as for their antioxidant and antibacterial activities.	en
dc.description.uri	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4446597/	en
dc.format.medium	Electronic	en
dc.language	English	en
dc.publisher	MDPI	en
dc.relation.ispartofseries	Marine Drugs	en
dc.rights	Items in ResearchSpace are protected by copyright, with all rights reserved, unless otherwise indicated. Previously published items are made available in accordance with the copyright policy of the publisher. Details obtained from http://sherpa.ac.uk/romeo/issn/1660-3397/ http://www.mdpi.com/about/openaccess	en
dc.rights.uri	https://researchspace.auckland.ac.nz/docs/uoa-docs/rights.htm	en
dc.rights.uri	https://creativecommons.org/licenses/by/4.0/	en
dc.subject	Animals	en
dc.subject	Porifera	en
dc.subject	Xestospongia	en
dc.subject	Bacteria	en
dc.subject	Naphthoquinones	en
dc.subject	Protein Kinases	en
dc.subject	Antioxidants	en
dc.subject	Anti-Bacterial Agents	en
dc.subject	Magnetic Resonance Spectroscopy	en
dc.subject	Cell Proliferation	en
dc.title	Novel Adociaquinone Derivatives from the Indonesian Sponge Xestospongia sp.	en
dc.type	Journal Article	en
dc.identifier.doi	10.3390/md13052617	en
pubs.issue	5	en
pubs.begin-page	2617	en
pubs.volume	13	en
dc.rights.holder	Copyright: The authors	en
dc.identifier.pmid	25927661	en
pubs.author-url	http://www.mdpi.com/1660-3397/13/5/2617	en
pubs.end-page	2628	en
pubs.publication-status	Published	en
dc.rights.accessrights	http://purl.org/eprint/accessRights/OpenAccess	en
pubs.subtype	Article	en
pubs.elements-id	487085	en
pubs.org-id	Science	en
pubs.org-id	Chemistry	en
pubs.org-id	Science Research	en
pubs.org-id	Maurice Wilkins Centre (2010-2014)	en
dc.identifier.eissn	1660-3397	en
pubs.record-created-at-source-date	2017-10-16	en
pubs.dimensions-id	25927661	en