Establishment of a Phenotypic-based Sand Dollar Fellaster zelandiae Embryo Development Assay and its Application in Defining the Structure-Activity Relationship of Discorhabdin Alkaloids

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dc.contributor.author Grkovic, T en
dc.contributor.author Copp, Brent en
dc.date.accessioned 2017-10-17T22:42:23Z en
dc.date.available 2013-02-22 en
dc.date.issued 2013-06 en
dc.identifier.citation Natural Product Communications, 8(6):699-700 Jun 2013 en
dc.identifier.issn 1934-578X en
dc.identifier.uri http://hdl.handle.net/2292/36125 en
dc.description.abstract An embryo development assay using the common New Zealand intertidal species Fellaster zelandiae (sand dollar) is presented. The assay was validated by comparing activity profiles of a range of discorhabdin alkaloids, natural products sourced from Latrunculia spp. sponges containing a core pyrido[2,3-h] pyrrolo[4,3,2-de]quinoline tetracyclic skeleton bound to various spiro-substituents at the C-6 position. Structural features on the discorhabdin molecule that correlated to the greatest degree of F. zelandiae embryo developmental inhibition were the presence of a spiro-dienone moiety and a C-2 bromine substituent. Based on the sand dollar embryo development assay results, a mechanism for the activity of the discorhabdin alkaloids is proposed. en
dc.language English en
dc.publisher Natural Product Incorporation en
dc.relation.ispartofseries Natural Product Communications en
dc.rights Items in ResearchSpace are protected by copyright, with all rights reserved, unless otherwise indicated. Previously published items are made available in accordance with the copyright policy of the publisher. Details obtained from http://sherpa.ac.uk/romeo/issn/1934-578X/ http://www.naturalproduct.us/InfoForAuthors.asp en
dc.rights.uri https://researchspace.auckland.ac.nz/docs/uoa-docs/rights.htm en
dc.subject Science & Technology en
dc.subject Life Sciences & Biomedicine en
dc.subject Chemistry, Medicinal en
dc.subject Food Science & Technology en
dc.subject Pharmacology & Pharmacy en
dc.subject CHEMISTRY, MEDICINAL en
dc.subject FOOD SCIENCE & TECHNOLOGY en
dc.subject Sand dollar en
dc.subject Echinoderm embryo development assay en
dc.subject Discorhabdin alkaloids en
dc.subject SPONGES en
dc.subject LATRUNCULIA en
dc.title Establishment of a Phenotypic-based Sand Dollar Fellaster zelandiae Embryo Development Assay and its Application in Defining the Structure-Activity Relationship of Discorhabdin Alkaloids en
dc.type Journal Article en
pubs.issue 6 en
pubs.begin-page 699 en
pubs.volume 8 en
dc.rights.holder Copyright: Natural Product Incorporation en
pubs.author-url http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000319855300006&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=6e41486220adb198d0efde5a3b153e7d en
pubs.end-page 700 en
pubs.publication-status Published en
dc.rights.accessrights http://purl.org/eprint/accessRights/RestrictedAccess en
pubs.subtype Article en
pubs.elements-id 404752 en
pubs.org-id Science en
pubs.org-id Chemistry en
pubs.org-id Science Research en
pubs.org-id Maurice Wilkins Centre (2010-2014) en
dc.identifier.eissn 1555-9475 en
pubs.record-created-at-source-date 2017-10-18 en


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