Allantoin as a Biomarker of Inflammation in an Inflammatory Bowel Disease Mouse Model: NMR Analysis of Urine

Show simple item record Dryland, Philippa en Love, Donald en Walker, Michael en Dommels, Y en Butts, C en Rowan, D en Roy, NC en Helsby, Nuala en Browning, Brian en Zhu, Shuotun en Copp, Brent en Ferguson, Lynnette en 2017-10-18T23:39:25Z en 2008-05-01 en 2008-06-03 en
dc.identifier.citation Open Bioactive Compounds Journal, 1:1-6, 2008 en
dc.identifier.issn 1874-8473 en
dc.identifier.uri en
dc.description.abstract Crohn’s disease (CD) is an Inflammatory Bowel Disease (IBD) that is characterised by destructive inflammation of the intestinal wall. Current methods for determining inflammation of the bowel are costly, time consuming and can cause discomfort to the patients. In order to address these problems, biomarker analysis of more accessible tissues is receiving increasing attention. Oxidative stress has been implicated in the promotion of inflammation. Allantoin has recently been reported as a biomarker for oxidative stress in human serum and urine. This paper investigates allantoin as a biomarker of inflammation in a mouse model of CD. Proton nuclear magnetic resonance (1H NMR) spectroscopy was used to analyse allantoin in urine from the mdr1a -/- mouse which is a model of CD. The data show that the levels of allantoin are strongly correlated with histological injury scores of mouse colonic tissue samples. Allantoin appears to be a useful biomarker of gut inflammation, involving oxidative stress, in a mouse model of CD and may be a potential biomarker in human CD studies en
dc.language English en
dc.publisher Bentham Open en
dc.relation.ispartofseries Open Bioactive Compounds Journal en
dc.rights Items in ResearchSpace are protected by copyright, with all rights reserved, unless otherwise indicated. Previously published items are made available in accordance with the copyright policy of the publisher. Details obtained from en
dc.rights.uri en
dc.rights.uri en
dc.title Allantoin as a Biomarker of Inflammation in an Inflammatory Bowel Disease Mouse Model: NMR Analysis of Urine en
dc.type Journal Article en
dc.identifier.doi 10.2174/1874847300801010001 en
pubs.begin-page 1 en
pubs.volume 1 en
dc.rights.holder Copyright: The authors en en
pubs.end-page 6 en
pubs.publication-status Published en
dc.rights.accessrights en
pubs.subtype Article en
pubs.elements-id 79882 en Medical and Health Sciences en Medical Sciences en Molecular Medicine en Science en Biological Sciences en Chemistry en Science Research en Maurice Wilkins Centre (2010-2014) en
dc.identifier.eissn 1874-8473 en
pubs.record-created-at-source-date 2010-09-01 en

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