Combined therapy with tiotropium and formoterol in chronic pulmonary disease: Effect on the 6-minute walk test

Show simple item record Jayaram, L en Wong, Conroy en McAuley, S en Rea, Harold en Zeng, Sui en O'Dochartaigh, C en 2017-10-19T01:27:50Z en 2013 en
dc.identifier.citation COPD: Journal of Chronic Obstructive Pulmonary Disease 10(4):466-472 2013 en
dc.identifier.issn 1541-2555 en
dc.identifier.uri en
dc.description.abstract Combined therapy with tiotropium and long-acting beta 2 agonists confers additional improvement in symptoms, lung function and aspects of health-related quality of life (QOL) compared with each drug alone in patients with COPD. However, the efficacy of combined therapy on walking distance, a surrogate measure of daily functional activity and morbidity remains unclear. The aim was, therefore, to quantify the benefit of this therapy on the six minute walk test. Secondary outcomes included change in lung function, symptoms, the BODE index and QOL. In a double-blind, crossover study, 38 participants with moderate to severe COPD on tiotropium were randomised to receive either formoterol or placebo for 6 weeks. Following a 2-week washout period, participants crossed over to the alternate arm of therapy for a further 6 weeks. Thirty-six participants, with an average age of 64.3 years and FEV1 predicted of 53%, completed the study. Combined therapy improved walking distance by a mean of 36 metres [95% CI: 2.4, 70.1; p = 0.04] compared with tiotropium. FEV1 increased in both groups (160 mL combination therapy versus 30 mL tiotropium) with a mean difference of 110 mL (95% CI: -100, 320; p = 0.07) between groups, These findings further support the emerging advantages of combined therapy in COPD. Australian New Zealand Clinical Trials. en
dc.publisher Taylor & Francis en
dc.relation.ispartofseries COPD: Journal of Chronic Obstructive Pulmonary Disease en
dc.rights Items in ResearchSpace are protected by copyright, with all rights reserved, unless otherwise indicated. Previously published items are made available in accordance with the copyright policy of the publisher. en
dc.rights.uri en
dc.title Combined therapy with tiotropium and formoterol in chronic pulmonary disease: Effect on the 6-minute walk test en
dc.type Journal Article en
dc.identifier.doi 10.3109/15412555.2013.771162 en
pubs.issue 4 en
pubs.begin-page 466 en
pubs.volume 10 en
dc.rights.holder Copyright: Taylor & Francis en
dc.identifier.pmid 23875741 en
pubs.end-page 472 en
dc.rights.accessrights en
pubs.subtype Article en
pubs.elements-id 375766 en Medical and Health Sciences en School of Medicine en Medicine Department en
dc.identifier.eissn 1541-2563 en
pubs.record-created-at-source-date 2013-04-12 en
pubs.dimensions-id 23875741 en

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