Didemnidines A and B, indole spermidine alkaloids from the New Zealand ascidian Didemnum sp.

Finlayson, R; Pearce, Allison; Page, MJ; Kaiser, M; Bourguet-Kondracki, M-L; Harper, JL; Webb, VL; Copp, Brent

dc.contributor.author	Finlayson, R	en
dc.contributor.author	Pearce, Allison	en
dc.contributor.author	Page, MJ	en
dc.contributor.author	Kaiser, M	en
dc.contributor.author	Bourguet-Kondracki, M-L	en
dc.contributor.author	Harper, JL	en
dc.contributor.author	Webb, VL	en
dc.contributor.author	Copp, Brent	en
dc.coverage.spatial	United States	en
dc.date.accessioned	2017-10-19T03:43:04Z	en
dc.date.issued	2011-02-24	en
dc.identifier.citation	Journal of Natural Products, 74(4):888-892, 24 Feb 2011	en
dc.identifier.issn	0163-3864	en
dc.identifier.uri	http://hdl.handle.net/2292/36166	en
dc.description.abstract	Two new indole spermidine alkaloids, didemnidines A (1) and B (2), have been isolated from the New Zealand ascidian Didemnum sp. The structures of the metabolites, determined by analysis of 2D NMR spectra and confirmed via synthesis, embody an indole-3-glyoxylamide moiety linked to the N(1) position of spermidine, the latter motif being particularly rare among marine natural products. Didemnidine B and a synthetic precursor exhibited mild in vitro growth inhibition of Plasmodium falciparum with IC(50)'s of 15 and 8.4 μM, respectively.	en
dc.description.uri	https://www.ncbi.nlm.nih.gov/pubmed/21348447	en
dc.language	English	en
dc.publisher	American Chemical Society	en
dc.relation.ispartofseries	J Nat Prod	en
dc.rights	Items in ResearchSpace are protected by copyright, with all rights reserved, unless otherwise indicated. Previously published items are made available in accordance with the copyright policy of the publisher. Details obtained from http://sherpa.ac.uk/romeo/issn/0163-3864/	en
dc.rights.uri	https://researchspace.auckland.ac.nz/docs/uoa-docs/rights.htm	en
dc.subject	Animals	en
dc.subject	Antiprotozoal Agents	en
dc.subject	Indole Alkaloids	en
dc.subject	Leishmania donovani	en
dc.subject	Molecular Structure	en
dc.subject	New Zealand	en
dc.subject	Nuclear Magnetic Resonance, Biomolecular	en
dc.subject	Plasmodium falciparum	en
dc.subject	Spermidine	en
dc.subject	Structure-Activity Relationship	en
dc.subject	Trypanosoma	en
dc.subject	Urochordata	en
dc.title	Didemnidines A and B, indole spermidine alkaloids from the New Zealand ascidian Didemnum sp.	en
dc.type	Journal Article	en
dc.identifier.doi	10.1021/np1008619	en
pubs.issue	4	en
pubs.begin-page	888	en
pubs.volume	74	en
dc.rights.holder	Copyright: American Chemical Society	en
dc.identifier.pmid	21348447	en
pubs.author-url	http://pubs.acs.org/doi/abs/10.1021/np1008619	en
pubs.end-page	892	en
pubs.publication-status	Published	en
dc.rights.accessrights	http://purl.org/eprint/accessRights/RestrictedAccess	en
pubs.subtype	Article	en
pubs.elements-id	206832	en
pubs.org-id	Science	en
pubs.org-id	Chemistry	en
pubs.org-id	Science Research	en
pubs.org-id	Maurice Wilkins Centre (2010-2014)	en
dc.identifier.eissn	1520-6025	en
pubs.record-created-at-source-date	2017-10-19	en
pubs.dimensions-id	21348447	en