dc.contributor.author |
Grkovic, T |
en |
dc.contributor.author |
Pearce, Allison |
en |
dc.contributor.author |
Munro, MHG |
en |
dc.contributor.author |
Blunt, JW |
en |
dc.contributor.author |
Davies-Coleman, MT |
en |
dc.contributor.author |
Copp, Brent |
en |
dc.date.accessioned |
2017-10-20T03:38:48Z |
en |
dc.date.issued |
2010-10-22 |
en |
dc.identifier.citation |
Journal of Natural Products, 73(10):1686-1693, 22 Oct 2010 |
en |
dc.identifier.issn |
0163-3864 |
en |
dc.identifier.uri |
http://hdl.handle.net/2292/36187 |
en |
dc.description.abstract |
Investigations of four different sponge populations of Latrunculia species collected in New Zealand waters has led to the characterization of a new diastereomer of discorhabdin H, named discorhabdin H2, confirmation of the structure of discorhabdin K ((+)-7), and presentation of a new diastereomer, discorhabdin K2 ((−)-8). In each case the structures were established by extensive NMR and MS studies and the absolute configurations interrogated by electronic circular dichroism (ECD). Absolute configurations were assigned to the known metabolites discorhabdins H, D, 2-hydroxy-D, N, and Q by comparison of ECD spectra with those recorded for discorhabdin alkaloids of defined absolute configuration, while the configurations of discorhabdins S, T, and U were assigned by semisynthesis from (+)-(6S,8S)-discorhabdin B. |
en |
dc.description.uri |
https://www.ncbi.nlm.nih.gov/pubmed/20860391 |
en |
dc.language |
English |
en |
dc.publisher |
American Chemical Society |
en |
dc.relation.ispartofseries |
Journal of Natural Products |
en |
dc.rights |
Items in ResearchSpace are protected by copyright, with all rights reserved, unless otherwise indicated. Previously published items are made available in accordance with the copyright policy of the publisher. Details obtained from http://sherpa.ac.uk/romeo/issn/0163-3864/ |
en |
dc.rights.uri |
https://researchspace.auckland.ac.nz/docs/uoa-docs/rights.htm |
en |
dc.subject |
Science & Technology |
en |
dc.subject |
Life Sciences & Biomedicine |
en |
dc.subject |
Plant Sciences |
en |
dc.subject |
Chemistry, Medicinal |
en |
dc.subject |
Pharmacology & Pharmacy |
en |
dc.subject |
CHEMISTRY, MEDICINAL |
en |
dc.subject |
PHARMACOLOGY & PHARMACY |
en |
dc.subject |
PLANT SCIENCES |
en |
dc.subject |
SPONGE PRIANOS-MELANOS |
en |
dc.subject |
WATER CARIBBEAN SPONGE |
en |
dc.subject |
GENUS LATRUNCULIA |
en |
dc.subject |
MARINE SPONGES |
en |
dc.subject |
CYTOTOXIC PYRROLOIMINOQUINONES |
en |
dc.subject |
ALKALOIDS |
en |
dc.subject |
METABOLITES |
en |
dc.subject |
BATZELLA |
en |
dc.subject |
PIGMENT |
en |
dc.subject |
BREVIS |
en |
dc.title |
Isolation and Characterization of Diastereomers of Discorhabdins H and K and Assignment of Absolute Configuration to Discorhabdins D, N, Q, S, T, and U |
en |
dc.type |
Journal Article |
en |
dc.identifier.doi |
10.1021/np100443c |
en |
pubs.issue |
10 |
en |
pubs.begin-page |
1686 |
en |
pubs.volume |
73 |
en |
dc.rights.holder |
Copyright: American Chemical Society |
en |
dc.identifier.pmid |
20860391 |
en |
pubs.author-url |
http://pubs.acs.org/doi/abs/10.1021/np100443c |
en |
pubs.end-page |
1693 |
en |
pubs.publication-status |
Published |
en |
dc.rights.accessrights |
http://purl.org/eprint/accessRights/RestrictedAccess |
en |
pubs.subtype |
Article |
en |
pubs.elements-id |
172843 |
en |
pubs.org-id |
Science |
en |
pubs.org-id |
Chemistry |
en |
pubs.org-id |
Science Research |
en |
pubs.org-id |
Maurice Wilkins Centre (2010-2014) |
en |
dc.identifier.eissn |
1520-6025 |
en |
pubs.record-created-at-source-date |
2017-10-20 |
en |
pubs.dimensions-id |
20860391 |
en |