Isodiplamine, cystodytin K and lissoclinidine: Novel bioactive alkaloids from the New Zealand ascidian Lissoclinum notti

Appleton, David; Pearce, Allison; Lambert, G; Babcock, Russell; Copp, Brent

dc.contributor.author	Appleton, David	en
dc.contributor.author	Pearce, Allison	en
dc.contributor.author	Lambert, G	en
dc.contributor.author	Babcock, Russell	en
dc.contributor.author	Copp, Brent	en
dc.date.accessioned	2017-10-24T23:53:32Z	en
dc.date.issued	2002	en
dc.identifier.citation	Tetrahedron 58(49):9779-9783 2002	en
dc.identifier.issn	0040-4020	en
dc.identifier.uri	http://hdl.handle.net/2292/36220	en
dc.description.abstract	A study of the bioactive crude extract of the New Zealand ascidian Lissoclinum notti led to the isolation of the new pyridoacridine alkaloids isodiplamine (4), cystodytin K (5) and lissoclinidine (6), as well as the known pyridoacridine alkaloids diplamine (7) and cystodytin J (8) and the benzopentathiepin varacin (3) and related trithiane varacin A. The new alkaloids were characterised using standard spectroscopic techniques, including 2D 1H–15N NMR experiments. Pyridoacridine alkaloids 4–8 were assayed for a range of biological activities including antitumour and antibiotic properties.	en
dc.publisher	Elsevier	en
dc.relation.ispartofseries	Tetrahedron	en
dc.rights	Items in ResearchSpace are protected by copyright, with all rights reserved, unless otherwise indicated. Previously published items are made available in accordance with the copyright policy of the publisher.	en
dc.rights.uri	https://researchspace.auckland.ac.nz/docs/uoa-docs/rights.htm	en
dc.title	Isodiplamine, cystodytin K and lissoclinidine: Novel bioactive alkaloids from the New Zealand ascidian Lissoclinum notti	en
dc.type	Journal Article	en
dc.identifier.doi	10.1016/S0040-4020(02)01296-6	en
pubs.issue	49	en
pubs.begin-page	9779	en
pubs.volume	58	en
dc.rights.holder	Copyright: Elsevier	en
pubs.end-page	9783	en
dc.rights.accessrights	http://purl.org/eprint/accessRights/RestrictedAccess	en
pubs.subtype	Article	en
pubs.elements-id	5412	en
pubs.org-id	Science	en
pubs.org-id	Chemistry	en
pubs.org-id	Science Research	en
pubs.org-id	Maurice Wilkins Centre (2010-2014)	en
pubs.record-created-at-source-date	2010-09-01	en