Technology for high-throughput screens: the present and future using zebrafish

Love, Donald; Pichler, Franz; Dodd, Andrew; Copp, Brent; Greenwood, David

dc.contributor.author	Love, Donald	en
dc.contributor.author	Pichler, Franz	en
dc.contributor.author	Dodd, Andrew	en
dc.contributor.author	Copp, Brent	en
dc.contributor.author	Greenwood, David	en
dc.date.accessioned	2017-10-29T22:49:12Z	en
dc.date.issued	2004-12	en
dc.identifier.citation	Current Opinion in Biotechnology, 15(6):564-571 Dec 2004	en
dc.identifier.issn	0958-1669	en
dc.identifier.uri	http://hdl.handle.net/2292/36280	en
dc.description.abstract	The zebrafish is a popular vertebrate model organism with similar organ systems and gene sequences to humans. Zebrafish embryos are optically transparent enabling organ visualisation, which can be complemented with gene expression analysis at the transcript and protein levels. Furthermore, zebrafish can be treated with small molecules and drugs in a microtitre plate format for high-throughput analysis and for the identification and validation of drugs. High-throughput methodologies for use in zebrafish include phenotype-based visualisation, transcript studies using low-density DNA microarrays and proteomic analysis. These technologies offer significant whole-organism biological value in the drug discovery and drug development pipeline.	en
dc.description.uri	https://www.ncbi.nlm.nih.gov/pubmed/15560983	en
dc.language	English	en
dc.publisher	Elsevier	en
dc.relation.ispartofseries	Current Opinion in Biotechnology	en
dc.rights	Items in ResearchSpace are protected by copyright, with all rights reserved, unless otherwise indicated. Previously published items are made available in accordance with the copyright policy of the publisher. Details obtained from http://sherpa.ac.uk/romeo/issn/0958-1669/ https://www.elsevier.com/about/our-business/policies/sharing	en
dc.rights.uri	https://researchspace.auckland.ac.nz/docs/uoa-docs/rights.htm	en
dc.title	Technology for high-throughput screens: the present and future using zebrafish	en
dc.type	Journal Article	en
dc.identifier.doi	10.1016/j.copbio.2004.09.004	en
pubs.issue	6	en
pubs.begin-page	564	en
pubs.volume	15	en
dc.rights.holder	Copyright: Elsevier	en
dc.identifier.pmid	15560983	en
pubs.author-url	http://www.sciencedirect.com/science/article/pii/S095816690400134X	en
pubs.end-page	571	en
pubs.publication-status	Published	en
dc.rights.accessrights	http://purl.org/eprint/accessRights/RestrictedAccess	en
pubs.subtype	Article	en
pubs.elements-id	7768	en
pubs.org-id	Science	en
pubs.org-id	Chemistry	en
pubs.org-id	Science Research	en
pubs.org-id	Maurice Wilkins Centre (2010-2014)	en
dc.identifier.eissn	1879-0429	en
pubs.record-created-at-source-date	2010-09-01	en
pubs.online-publication-date	2004-10-13	en
pubs.dimensions-id	15560983	en