Technology for high-throughput screens: the present and future using zebrafish

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dc.contributor.author Love, Donald en
dc.contributor.author Pichler, Franz en
dc.contributor.author Dodd, Andrew en
dc.contributor.author Copp, Brent en
dc.contributor.author Greenwood, David en
dc.date.accessioned 2017-10-29T22:49:12Z en
dc.date.issued 2004-12 en
dc.identifier.citation Current Opinion in Biotechnology, 15(6):564-571 Dec 2004 en
dc.identifier.issn 0958-1669 en
dc.identifier.uri http://hdl.handle.net/2292/36280 en
dc.description.abstract The zebrafish is a popular vertebrate model organism with similar organ systems and gene sequences to humans. Zebrafish embryos are optically transparent enabling organ visualisation, which can be complemented with gene expression analysis at the transcript and protein levels. Furthermore, zebrafish can be treated with small molecules and drugs in a microtitre plate format for high-throughput analysis and for the identification and validation of drugs. High-throughput methodologies for use in zebrafish include phenotype-based visualisation, transcript studies using low-density DNA microarrays and proteomic analysis. These technologies offer significant whole-organism biological value in the drug discovery and drug development pipeline. en
dc.description.uri https://www.ncbi.nlm.nih.gov/pubmed/15560983 en
dc.language English en
dc.publisher Elsevier en
dc.relation.ispartofseries Current Opinion in Biotechnology en
dc.rights Items in ResearchSpace are protected by copyright, with all rights reserved, unless otherwise indicated. Previously published items are made available in accordance with the copyright policy of the publisher. Details obtained from http://sherpa.ac.uk/romeo/issn/0958-1669/ https://www.elsevier.com/about/our-business/policies/sharing en
dc.rights.uri https://researchspace.auckland.ac.nz/docs/uoa-docs/rights.htm en
dc.title Technology for high-throughput screens: the present and future using zebrafish en
dc.type Journal Article en
dc.identifier.doi 10.1016/j.copbio.2004.09.004 en
pubs.issue 6 en
pubs.begin-page 564 en
pubs.volume 15 en
dc.rights.holder Copyright: Elsevier en
dc.identifier.pmid 15560983 en
pubs.author-url http://www.sciencedirect.com/science/article/pii/S095816690400134X en
pubs.end-page 571 en
pubs.publication-status Published en
dc.rights.accessrights http://purl.org/eprint/accessRights/RestrictedAccess en
pubs.subtype Article en
pubs.elements-id 7768 en
pubs.org-id Science en
pubs.org-id Chemistry en
pubs.org-id Science Research en
pubs.org-id Maurice Wilkins Centre (2010-2014) en
dc.identifier.eissn 1879-0429 en
pubs.record-created-at-source-date 2010-09-01 en
pubs.online-publication-date 2004-10-13 en
pubs.dimensions-id 15560983 en


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