Chemical discovery and global gene expression analysis in zebrafish

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Show simple item record Pichler, Franz en Laurenson, S en Williams, Liam en Dodd, A en Copp, Brent en Love, Donald en 2017-11-06T04:24:28Z en 2003-08 en
dc.identifier.citation Nature Biotechnology, 21(8):879-883 Aug 2003 en
dc.identifier.issn 1087-0156 en
dc.identifier.uri en
dc.description.abstract The zebrafish (Danio rerio) provides an excellent model for studying vertebrate development and human disease because of its ex utero, optically transparent embryogenesis and amenability to in vivo manipulation. The rapid embryonic developmental cycle, large clutch sizes and ease of maintenance at large numbers also add to the appeal of this species. Considerable genomic data has recently become publicly available that is aiding the construction of zebrafish microarrays, thus permitting global gene expression analysis. The zebrafish is also suitable for chemical genomics, in part as a result of the permeability of its embryos to small molecules and consequent avoidance of external confounding maternal effects. Finally, there is increasing characterization and analysis of zebrafish models of human disease. Thus, the zebrafish offers a high-quality, high-throughput bioassay tool for determining the biological effect of small molecules as well as for dissecting biological pathways. en
dc.description.uri en
dc.language English en
dc.publisher Nature Publishing Group en
dc.relation.ispartofseries Nature Biotechnology en
dc.rights Items in ResearchSpace are protected by copyright, with all rights reserved, unless otherwise indicated. Previously published items are made available in accordance with the copyright policy of the publisher. Details obtained from en
dc.rights.uri en
dc.title Chemical discovery and global gene expression analysis in zebrafish en
dc.type Journal Article en
dc.identifier.doi 10.1038/nbt852 en
pubs.issue 8 en
pubs.begin-page 879 en
pubs.volume 21 en
dc.rights.holder Copyright: Nature Publishing Group en
dc.identifier.pmid 12894204 en en
pubs.end-page 883 en
pubs.publication-status Published en
dc.rights.accessrights en
pubs.subtype Article en
pubs.elements-id 6203 en Science en Chemistry en Science Research en Maurice Wilkins Centre (2010-2014) en
dc.identifier.eissn 1546-1696 en
pubs.record-created-at-source-date 2010-09-01 en 2003-07-31 en
pubs.dimensions-id 12894204 en

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