dc.contributor.author |
Pichler, Franz |
en |
dc.contributor.author |
Laurenson, S |
en |
dc.contributor.author |
Williams, Liam |
en |
dc.contributor.author |
Dodd, A |
en |
dc.contributor.author |
Copp, Brent |
en |
dc.contributor.author |
Love, Donald |
en |
dc.date.accessioned |
2017-11-06T04:24:28Z |
en |
dc.date.issued |
2003-08 |
en |
dc.identifier.citation |
Nature Biotechnology, 21(8):879-883 Aug 2003 |
en |
dc.identifier.issn |
1087-0156 |
en |
dc.identifier.uri |
http://hdl.handle.net/2292/36331 |
en |
dc.description.abstract |
The zebrafish (Danio rerio) provides an excellent model for studying vertebrate development and human disease because of its ex utero, optically transparent embryogenesis and amenability to in vivo manipulation. The rapid embryonic developmental cycle, large clutch sizes and ease of maintenance at large numbers also add to the appeal of this species. Considerable genomic data has recently become publicly available that is aiding the construction of zebrafish microarrays, thus permitting global gene expression analysis. The zebrafish is also suitable for chemical genomics, in part as a result of the permeability of its embryos to small molecules and consequent avoidance of external confounding maternal effects. Finally, there is increasing characterization and analysis of zebrafish models of human disease. Thus, the zebrafish offers a high-quality, high-throughput bioassay tool for determining the biological effect of small molecules as well as for dissecting biological pathways. |
en |
dc.description.uri |
https://www.ncbi.nlm.nih.gov/pubmed/12894204 |
en |
dc.language |
English |
en |
dc.publisher |
Nature Publishing Group |
en |
dc.relation.ispartofseries |
Nature Biotechnology |
en |
dc.rights |
Items in ResearchSpace are protected by copyright, with all rights reserved, unless otherwise indicated. Previously published items are made available in accordance with the copyright policy of the publisher. Details obtained from http://sherpa.ac.uk/romeo/issn/1087-0156/
http://www.nature.com/authors/author_resources/deposition.html |
en |
dc.rights.uri |
https://researchspace.auckland.ac.nz/docs/uoa-docs/rights.htm |
en |
dc.title |
Chemical discovery and global gene expression analysis in zebrafish |
en |
dc.type |
Journal Article |
en |
dc.identifier.doi |
10.1038/nbt852 |
en |
pubs.issue |
8 |
en |
pubs.begin-page |
879 |
en |
pubs.volume |
21 |
en |
dc.rights.holder |
Copyright: Nature Publishing Group |
en |
dc.identifier.pmid |
12894204 |
en |
pubs.author-url |
https://www.nature.com/articles/nbt852 |
en |
pubs.end-page |
883 |
en |
pubs.publication-status |
Published |
en |
dc.rights.accessrights |
http://purl.org/eprint/accessRights/RestrictedAccess |
en |
pubs.subtype |
Article |
en |
pubs.elements-id |
6203 |
en |
pubs.org-id |
Science |
en |
pubs.org-id |
Chemistry |
en |
pubs.org-id |
Science Research |
en |
pubs.org-id |
Maurice Wilkins Centre (2010-2014) |
en |
dc.identifier.eissn |
1546-1696 |
en |
pubs.record-created-at-source-date |
2010-09-01 |
en |
pubs.online-publication-date |
2003-07-31 |
en |
pubs.dimensions-id |
12894204 |
en |