Antiparasitic activity of marine pyridoacridone alkaloids related to the ascididemins

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Show simple item record Copp, Brent en Kayser, O en Brun, R en Kiderlen, AF en 2017-11-06T23:12:12Z en 2003-02-15 en 2003-06 en
dc.identifier.citation Planta Medica, 69(6): 527-531 Jun 2003 en
dc.identifier.issn 0032-0943 en
dc.identifier.uri en
dc.description.abstract A series of pyridoacridone alkaloids, including the marine alkaloid ascididemin were tested in vitro for antiparasitic activity against P. falciparum (K1, NF54), L. donovani, T. cruzi, T. b. rhodesiense and two mammalian cell lines (L6, RAW 264.7). Most compounds showed high antiplasmodial activity, moderate antileishmanial activity against both extra- and intracellular forms, and significant trypanocidal effects against T. cruzi and T. b. brucei. However, when tested against mammalian cell lines, most of the compounds were also toxic for macrophage-like RAW 264.7 cells and skeletal muscle myoblast L6 cells. Correlations between molecular structures and antiparasitic activity are discussed in detail. Specific compounds are illustrated with emphasis on their potential as new antiparasitic drug leads. en
dc.description.uri en
dc.language English en
dc.publisher Thieme en
dc.relation.ispartofseries Planta Medica en
dc.rights Items in ResearchSpace are protected by copyright, with all rights reserved, unless otherwise indicated. Previously published items are made available in accordance with the copyright policy of the publisher. Details obtained from en
dc.rights.uri en
dc.title Antiparasitic activity of marine pyridoacridone alkaloids related to the ascididemins en
dc.type Journal Article en
dc.identifier.doi 10.1055/s-2003-40640 en
pubs.issue 6 en
pubs.begin-page 527 en
pubs.volume 69 en
dc.rights.holder Copyright: Thieme en
dc.identifier.pmid 12865971 en en
pubs.end-page 531 en
pubs.publication-status Published en
dc.rights.accessrights en
pubs.subtype Article en
pubs.elements-id 6143 en Science en Chemistry en Science Research en Maurice Wilkins Centre (2010-2014) en
dc.identifier.eissn 1439-0221 en
pubs.record-created-at-source-date 2010-09-01 en
pubs.dimensions-id 12865971 en

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