In vitro and in vivo biocompatibility of an Ag-bearing Zr-based bulk metallic glass for potential medical use

Show simple item record Sun, Y en Huang, Y en Fan, H en Wang, Y en Ning, Z en Liu, F en Feng, D en Jin, X en Shen, J en Sun, J en Chen, John en 2017-11-19T21:26:12Z en 2015-07 en
dc.identifier.citation Journal of Non-Crystalline Solids 419:82-91 Jul 2015 en
dc.identifier.issn 1873-4812 en
dc.identifier.uri en
dc.description.abstract A bulk metallic glass (BMG), Zr46(Cu4.5/5.5Ag1/5.5)46Al8 (ZrCuAlAg), has been prepared and systematically evaluated in terms of microstructure, corrosion resistance, wear resistance, cytotoxicity, and in vivo implantation, aiming at exploring its use as a novel biomedical material. For comparison, the above-mentioned tests were also performed on Zr51.9Cu23.3Ni10.5Al14.3, Zr51Ti5Ni10Cu25Al9, and Ti40Zr25Ni12Cu3Be20 BMGs, pure Ti and Ti–6Al–4V alloys. ZrCuAlAg BMG exhibits better corrosion resistance in both NaCl and Hank's solutions than other materials. The cell culture tests indicate that the BMGs exhibit a cytotoxicity of Grades 0–1, identical with pure Ti and Ti–6Al–4V alloys. Cell morphological analysis shows that the cells were flattened and well spread out on the surfaces of the BMGs, demonstrating their good cell compatibility. Animal tests proved that the ZrCuAlAg BMG implant performed as well as Ti–6Al–4V, without any obvious inflammation reaction at the implantation sites. The excellent biocompatibility of ZrCuAlAg BMG can be attributed to its amorphous structure-related high corrosion resistance as well as its unique composition, i.e. free of toxic Ni and Be, and containing biocompatible Ag element. It suggests that the Ag-bearing ZrCuAlAg BMG with excellent biocompatibility is promising for biomedical applications. en
dc.publisher Elsevier en
dc.relation.ispartofseries Journal of Non-Crystalline Solids en
dc.rights Items in ResearchSpace are protected by copyright, with all rights reserved, unless otherwise indicated. Previously published items are made available in accordance with the copyright policy of the publisher. en
dc.rights.uri en
dc.title In vitro and in vivo biocompatibility of an Ag-bearing Zr-based bulk metallic glass for potential medical use en
dc.type Journal Article en
dc.identifier.doi 10.1016/j.jnoncrysol.2015.03.039 en
pubs.begin-page 82 en
pubs.volume 419 en
dc.rights.holder Copyright: Elsevier en
pubs.end-page 91 en
pubs.publication-status Published en
dc.rights.accessrights en
pubs.subtype Article en
pubs.elements-id 486317 en
pubs.record-created-at-source-date 2017-11-20 en

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