dc.contributor.author |
Falconer, James |
en |
dc.contributor.author |
Wen, Jingyuan |
en |
dc.contributor.author |
Zargar-Shoshtari, S |
en |
dc.contributor.author |
Chen, John |
en |
dc.contributor.author |
Farid, Mohammed |
en |
dc.contributor.author |
Young, S |
en |
dc.contributor.author |
Alany, Raid |
en |
dc.date.accessioned |
2017-11-19T22:24:01Z |
en |
dc.date.issued |
2013 |
en |
dc.identifier.citation |
Journal of Drug Delivery Science and Technology 23(5):477-483 2013 |
en |
dc.identifier.issn |
1773-2247 |
en |
dc.identifier.uri |
http://hdl.handle.net/2292/36465 |
en |
dc.description.abstract |
The aim of this study was to determine the effect of supercritical carbon dioxide (SC-CO2) on the crystallinity and drug release of Gelucire 44/14-based endogenous progesterone (PGN) dispersion systems. The light scattering from PGN crystals incorporated in Gelucire 44/14 was imaged using optical microscopy. In vitro dissolution was used to determine the release kinetics of PGN, Gelucire 44/14, incorporated by a supercritical fluid (SCF) method. Release profiles were evaluated according to zero-order, first-order, Higuchi, Krosmeyer-Peppas, and dual first-order models. The dual first-order release model illustrated two distinct release rates: an initial rapid release followed by a slow diffusion of PGN from the dispersion systems. The dual first-order release model adds a new tool to the elucidation of release mechanisms from lipid and micelle-forming-based dispersion systems, where parallel processes contribute to drug release. |
en |
dc.publisher |
Elsevier |
en |
dc.relation.ispartofseries |
Journal of Drug Delivery Science and Technology |
en |
dc.rights |
Items in ResearchSpace are protected by copyright, with all rights reserved, unless otherwise indicated. Previously published items are made available in accordance with the copyright policy of the publisher. |
en |
dc.rights.uri |
https://researchspace.auckland.ac.nz/docs/uoa-docs/rights.htm |
en |
dc.title |
Effects of supercritical carbon dioxide processing on optical crystallinity and in vitro release of progesterone and Gelucire 44/14 solid and semi-solid dispersions |
en |
dc.type |
Journal Article |
en |
dc.identifier.doi |
10.1016/S1773-2247(13)50069-4 |
en |
pubs.issue |
5 |
en |
pubs.begin-page |
477 |
en |
pubs.volume |
23 |
en |
dc.rights.holder |
Copyright: Elsevier |
en |
pubs.end-page |
483 |
en |
dc.rights.accessrights |
http://purl.org/eprint/accessRights/RestrictedAccess |
en |
pubs.subtype |
Article |
en |
pubs.elements-id |
407343 |
en |
pubs.org-id |
Engineering |
en |
pubs.org-id |
Chemical and Materials Eng |
en |
pubs.org-id |
Medical and Health Sciences |
en |
pubs.org-id |
Pharmacy |
en |
pubs.record-created-at-source-date |
2013-11-18 |
en |