Naamidine A is an antagonist of the epidermal growth factor receptor and an in vivo active antitumor agent

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dc.contributor.author Copp, Brent en
dc.contributor.author Fairchild, CR en
dc.contributor.author Cornell, L en
dc.contributor.author Casazza, AM en
dc.contributor.author Robinson, S en
dc.contributor.author Ireland, CM en
dc.date.accessioned 2017-11-22T20:48:40Z en
dc.date.issued 1998 en
dc.identifier.citation Journal of Medicinal Chemistry, 41(20): 3909-3911, 1998 en
dc.identifier.issn 0022-2623 en
dc.identifier.uri http://hdl.handle.net/2292/36507 en
dc.description.abstract The known 2-aminoimidazole alkaloid naamidine A (1) was isolated from a Fijian Leucetta sp. sponge as an inhibitor of the epidermal growth factor (EGF) receptor. The compound exhibited potent ability to inhibit the EGF signaling pathway and is more specific for the EGF-mediated mitogenic response than for the insulin-mediated mitogenic response. Evaluation in an A431 xenograft tumor model in athymic mice indicated that naamidine A exhibited at least 85% growth inhibition at the maximal tolerated dose of 25 mg/kg. Preliminary mechanism of action studies indicate that the alkaloid fails to inhibit the binding of EGF to the receptor and has no effect on the catalytic activity of purified c-src tyrosine kinase. en
dc.description.uri https://www.ncbi.nlm.nih.gov/pubmed/9748366 en
dc.language English en
dc.publisher American Chemical Society en
dc.relation.ispartofseries Journal of Medicinal Chemistry en
dc.rights Items in ResearchSpace are protected by copyright, with all rights reserved, unless otherwise indicated. Previously published items are made available in accordance with the copyright policy of the publisher. Details obtained from http://sherpa.ac.uk/romeo/issn/0022-2623/ en
dc.rights.uri https://researchspace.auckland.ac.nz/docs/uoa-docs/rights.htm en
dc.title Naamidine A is an antagonist of the epidermal growth factor receptor and an in vivo active antitumor agent en
dc.type Journal Article en
dc.identifier.doi 10.1021/jm980294n en
pubs.issue 20 en
pubs.begin-page 3909 en
pubs.volume 41 en
dc.rights.holder Copyright: American Chemical Society en
dc.identifier.pmid 9748366 en
pubs.author-url http://pubs.acs.org/doi/abs/10.1021/jm980294n en
pubs.end-page 3911 en
pubs.publication-status Published en
dc.rights.accessrights http://purl.org/eprint/accessRights/RestrictedAccess en
pubs.subtype Article en
pubs.elements-id 37079 en
pubs.org-id Science en
pubs.org-id Chemistry en
pubs.org-id Science Research en
pubs.org-id Maurice Wilkins Centre (2010-2014) en
dc.identifier.eissn 1520-4804 en
pubs.record-created-at-source-date 2010-09-01 en
pubs.online-publication-date 1998-09-02 en
pubs.dimensions-id 9748366 en


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