Alzheimer's disease in the human eye. Clinical tests that identify ocular and visual information processing deficit as biomarkers

Show simple item record Chang, Yu-Li en Lowe, J en Ardiles, A en Lim, Julie en Grey, Angus en Robertson, K en Danesh-Meyer, Helen en Palacios, AG en Acosta Etchebarne, Monica en
dc.coverage.spatial United States en 2017-12-08T02:42:53Z en 2013-06-03 en 2014-03 en
dc.identifier.citation Alzheimers & Dementia, 10(2):251-261 March 2014 en
dc.identifier.issn 1552-5260 en
dc.identifier.uri en
dc.description.abstract Alzheimer's disease (AD) is the most common form of dementia with progressive deterioration of memory and cognition. Complaints related to vision are common among AD patients. Several changes in the retina, lens, and in the vasculature have been noted in the AD eye that may be the cause of visual symptoms experienced by the AD patient. Anatomical changes have been detected within the eye before signs of cognitive impairment and memory loss are apparent. Unlike the brain, the eye is a unique organ that can be visualized noninvasively at the cellular level because of its transparent nature, which allows for inexpensive testing of biomarkers in a clinical setting. In this review, we have searched for candidate biomarkers that could enable diagnosis of AD, covering ocular neurodegeneration associated with functional tests. We explore the evidence that suggests that inexpensive, noninvasive clinical tests could be used to detect AD ocular biomarkers. en
dc.description.uri en
dc.language English en
dc.publisher Elsevier en
dc.relation.ispartofseries Alzheimers & Dementia en
dc.rights Items in ResearchSpace are protected by copyright, with all rights reserved, unless otherwise indicated. Previously published items are made available in accordance with the copyright policy of the publisher. Details obtained from en
dc.rights.uri en
dc.subject Amyloid en
dc.subject Ganglion cells en
dc.subject Glaucoma en
dc.subject Retina en
dc.subject Retinal degeneration en
dc.subject Alzheimer Disease en
dc.subject Eye Diseases en
dc.subject Humans en
dc.subject Visual Pathways en
dc.title Alzheimer's disease in the human eye. Clinical tests that identify ocular and visual information processing deficit as biomarkers en
dc.type Journal Article en
dc.identifier.doi 10.1016/j.jalz.2013.06.004 en
pubs.issue 2 en
pubs.begin-page 251 en
pubs.volume 10 en
dc.rights.holder Copyright: Elsevier en
dc.identifier.pmid 24011928 en en
pubs.end-page 261 en
pubs.publication-status Published en
dc.rights.accessrights en
pubs.subtype Review en
pubs.elements-id 406486 en Medical and Health Sciences en Medical Sciences en Physiology Division en Optometry and Vision Science en School of Medicine en Ophthalmology Department en
dc.identifier.eissn 1552-5279 en
dc.identifier.pii S1552-5260(13)02469-2 en
pubs.record-created-at-source-date 2017-12-08 en 2013-09-05 en
pubs.dimensions-id 24011928 en

Files in this item

Find Full text

This item appears in the following Collection(s)

Show simple item record


Search ResearchSpace