dc.contributor.author |
Nivison-Smith, L |
en |
dc.contributor.author |
O'Brien, BJ |
en |
dc.contributor.author |
Truong, M |
en |
dc.contributor.author |
Guo, Xiaopeng |
en |
dc.contributor.author |
Kalloniatis, M |
en |
dc.contributor.author |
Acosta Etchebarne, Monica |
en |
dc.date.accessioned |
2017-12-11T02:22:45Z |
en |
dc.date.issued |
2015-05 |
en |
dc.identifier.citation |
American Journal of Physiology - Cell Physiology, 308(9):C737-C749 May 2015 |
en |
dc.identifier.issn |
0363-6143 |
en |
dc.identifier.uri |
http://hdl.handle.net/2292/36724 |
en |
dc.description.abstract |
Vinpocetine protects against a range of degenerative conditions and insults of the central nervous system via multiple modes of action. Little is known, however, of its effects on metabolism. This may be highly relevant, as vinpocetine is highly protective against ischemia, a process that inhibits normal metabolic function. This study uses the ischemic retina as a model to characterize vinpocetine's effects on metabolism. Vinpocetine reduced the metabolic demand of the retina following ex vivo hypoxia and ischemia to normal levels based on lactate dehydrogenase activity. Vinpocetine delivered similar effects in an in vivo model of retinal ischemia-reperfusion, possibly through increasing glucose availability. Vinpocetine's effects on glucose also appeared to improve glutamate homeostasis in ischemic Müller cells. Other actions of vinpocetine following ischemia-reperfusion, such as reduced cell death and improved retinal function, were possibly a combination of the drug's actions on metabolism and other retinal pathways. Vinpocetine's metabolic effects appeared independent of its other known actions in ischemia, as it recovered retinal function in a separate metabolic model where the glutamate-to-glutamine metabolic pathway was inhibited in Müller cells. The results of this study indicate that vinpocetine mediates ischemic damage partly through altered metabolism and has potential beneficial effects as a treatment for ischemia of neuronal tissues. |
en |
dc.description.uri |
https://www.ncbi.nlm.nih.gov/pubmed/25696811 |
en |
dc.format.medium |
Print-Electronic |
en |
dc.language |
English |
en |
dc.publisher |
American Physiological Society |
en |
dc.relation.ispartofseries |
American Journal of Physiology - Cell Physiology |
en |
dc.rights |
Items in ResearchSpace are protected by copyright, with all rights reserved, unless otherwise indicated. Previously published items are made available in accordance with the copyright policy of the publisher. Details obtained from http://sherpa.ac.uk/romeo/issn/0363-6143/
http://www.the-aps.org/mm/Publications/Info-For-Authors/Copyright |
en |
dc.rights.uri |
https://researchspace.auckland.ac.nz/docs/uoa-docs/rights.htm |
en |
dc.subject |
Animals |
en |
dc.subject |
Rats, Sprague-Dawley |
en |
dc.subject |
Retinal Diseases |
en |
dc.subject |
Ischemia |
en |
dc.subject |
Disease Models, Animal |
en |
dc.subject |
Vinca Alkaloids |
en |
dc.subject |
L-Lactate Dehydrogenase |
en |
dc.subject |
Glucose |
en |
dc.subject |
Glutamic Acid |
en |
dc.subject |
Neuroprotective Agents |
en |
dc.subject |
Electroretinography |
en |
dc.subject |
Tissue Culture Techniques |
en |
dc.subject |
Cell Death |
en |
dc.subject |
Energy Metabolism |
en |
dc.subject |
Evoked Potentials |
en |
dc.subject |
Cytoprotection |
en |
dc.subject |
Dose-Response Relationship, Drug |
en |
dc.subject |
Ependymoglial Cells |
en |
dc.title |
Vinpocetine modulates metabolic activity and function during retinal ischemia |
en |
dc.type |
Journal Article |
en |
dc.identifier.doi |
10.1152/ajpcell.00291.2014 |
en |
pubs.issue |
9 |
en |
pubs.begin-page |
C737 |
en |
pubs.volume |
308 |
en |
dc.rights.holder |
Copyright: American Physiological Society |
en |
dc.identifier.pmid |
25696811 |
en |
pubs.author-url |
http://www.physiology.org/doi/10.1152/ajpcell.00291.2014 |
en |
pubs.end-page |
C749 |
en |
pubs.publication-status |
Published |
en |
dc.rights.accessrights |
http://purl.org/eprint/accessRights/RestrictedAccess |
en |
pubs.subtype |
Article |
en |
pubs.elements-id |
487220 |
en |
pubs.org-id |
Medical and Health Sciences |
en |
pubs.org-id |
Optometry and Vision Science |
en |
dc.identifier.eissn |
1522-1563 |
en |
pubs.record-created-at-source-date |
2017-12-11 |
en |
pubs.dimensions-id |
25696811 |
en |