Maternal serum IGF-1, IGFBP-1 and 3, and placental growth hormone at 20 weeks’ gestation in pregnancies complicated by preeclampsia

Show simple item record Liao, S en Vickers, Mark en Taylor, Rennae en Jones, B en Fraser, Mhoyra en McCowan, Lesley en Baker, Philip en Perry, Johanna en 2017-12-20T03:52:53Z en 2017-07-25 en 2017-10 en
dc.identifier.citation Pregnancy Hypertension, 10:149-154 Oct 2017 en
dc.identifier.issn 2210-7789 en
dc.identifier.uri en
dc.description.abstract To investigate whether maternal serum concentrations of placental growth hormone (GH-V), insulin-like growth factor (IGF) 1 and 2, and IGF binding proteins (IGFBP) 1 and 3 were altered in pregnancies complicated by later preeclampsia (PE). In a nested case-control study, PE cases (n=71) and matched controls (n=71) were selected from the Screening for Pregnancy Endpoints (SCOPE) biobank in Auckland, New Zealand. Maternal serum hormone concentrations at 20weeks of gestation were determined by ELISA. We found that maternal serum GH-V concentration at 20weeks of gestation was unaltered in the PE group, compared to the control group (median, 1.78ng/ml vs. 1.65ng/ml, p=0.884). Maternal IGF-1 and IGFBP-3 concentrations and the IGF-1/IGFBP-3 ratio in PE pregnancies were significantly higher than in controls (median, 253.1ng/ml vs. 204.3ng/ml, p<0.0001; 8535ng/ml vs. 7711ng/ml, p=0.0023; 0.032vs. 0.026, p<0.0001, respectively), whereas maternal IGFBP-1 concentration was significantly lower in PE pregnancies than in controls (median, 34.85ng/ml vs. 48.92ng/ml, p=0.0006). Our findings suggest a potential role of IGFs and IGFBPs in the prediction of pregnancies complicated by PE. However, the maternal serum concentration of GH-V at 20weeks’ gestation is unlikely to be useful in the early prediction of PE. en
dc.description.uri en
dc.language English en
dc.publisher Elsevier en
dc.relation.ispartofseries Pregnancy Hypertension en
dc.rights Items in ResearchSpace are protected by copyright, with all rights reserved, unless otherwise indicated. Previously published items are made available in accordance with the copyright policy of the publisher. Details obtained from en
dc.rights.uri en
dc.title Maternal serum IGF-1, IGFBP-1 and 3, and placental growth hormone at 20 weeks’ gestation in pregnancies complicated by preeclampsia en
dc.type Journal Article en
dc.identifier.doi 10.1016/j.preghy.2017.07.148 en
pubs.begin-page 149 en
pubs.volume 10 en
dc.rights.holder Copyright: Elsevier en
dc.identifier.pmid 29153669 en en
pubs.end-page 154 en
pubs.publication-status Published en
dc.rights.accessrights en
pubs.subtype Article en
pubs.elements-id 649260 en Liggins Institute en Medical and Health Sciences en Medical Sciences en Physiology Division en School of Medicine en Obstetrics and Gynaecology en Science en Statistics en
dc.identifier.eissn 2210-7797 en
pubs.record-created-at-source-date 2017-08-16 en 2017-07-27 en
pubs.dimensions-id 29153669 en

Files in this item

Find Full text

This item appears in the following Collection(s)

Show simple item record


Search ResearchSpace