dc.contributor.author |
Liao, S |
en |
dc.contributor.author |
Vickers, Mark |
en |
dc.contributor.author |
Taylor, Rennae |
en |
dc.contributor.author |
Jones, B |
en |
dc.contributor.author |
Fraser, Mhoyra |
en |
dc.contributor.author |
McCowan, Lesley |
en |
dc.contributor.author |
Baker, Philip |
en |
dc.contributor.author |
Perry, Johanna |
en |
dc.date.accessioned |
2017-12-20T03:52:53Z |
en |
dc.date.available |
2017-07-25 |
en |
dc.date.issued |
2017-10 |
en |
dc.identifier.citation |
Pregnancy Hypertension, 10:149-154 Oct 2017 |
en |
dc.identifier.issn |
2210-7789 |
en |
dc.identifier.uri |
http://hdl.handle.net/2292/36804 |
en |
dc.description.abstract |
To investigate whether maternal serum concentrations of placental growth hormone (GH-V), insulin-like growth factor (IGF) 1 and 2, and IGF binding proteins (IGFBP) 1 and 3 were altered in pregnancies complicated by later preeclampsia (PE). In a nested case-control study, PE cases (n=71) and matched controls (n=71) were selected from the Screening for Pregnancy Endpoints (SCOPE) biobank in Auckland, New Zealand. Maternal serum hormone concentrations at 20weeks of gestation were determined by ELISA. We found that maternal serum GH-V concentration at 20weeks of gestation was unaltered in the PE group, compared to the control group (median, 1.78ng/ml vs. 1.65ng/ml, p=0.884). Maternal IGF-1 and IGFBP-3 concentrations and the IGF-1/IGFBP-3 ratio in PE pregnancies were significantly higher than in controls (median, 253.1ng/ml vs. 204.3ng/ml, p<0.0001; 8535ng/ml vs. 7711ng/ml, p=0.0023; 0.032vs. 0.026, p<0.0001, respectively), whereas maternal IGFBP-1 concentration was significantly lower in PE pregnancies than in controls (median, 34.85ng/ml vs. 48.92ng/ml, p=0.0006). Our findings suggest a potential role of IGFs and IGFBPs in the prediction of pregnancies complicated by PE. However, the maternal serum concentration of GH-V at 20weeks’ gestation is unlikely to be useful in the early prediction of PE. |
en |
dc.description.uri |
https://www.ncbi.nlm.nih.gov/pubmed/29153669 |
en |
dc.language |
English |
en |
dc.publisher |
Elsevier |
en |
dc.relation.ispartofseries |
Pregnancy Hypertension |
en |
dc.rights |
Items in ResearchSpace are protected by copyright, with all rights reserved, unless otherwise indicated. Previously published items are made available in accordance with the copyright policy of the publisher. Details obtained from http://sherpa.ac.uk/romeo/issn/2210-7789/
https://www.elsevier.com/about/our-business/policies/sharing |
en |
dc.rights.uri |
https://researchspace.auckland.ac.nz/docs/uoa-docs/rights.htm |
en |
dc.title |
Maternal serum IGF-1, IGFBP-1 and 3, and placental growth hormone at 20 weeks’ gestation in pregnancies complicated by preeclampsia |
en |
dc.type |
Journal Article |
en |
dc.identifier.doi |
10.1016/j.preghy.2017.07.148 |
en |
pubs.begin-page |
149 |
en |
pubs.volume |
10 |
en |
dc.rights.holder |
Copyright: Elsevier |
en |
dc.identifier.pmid |
29153669 |
en |
pubs.author-url |
http://www.sciencedirect.com/science/article/pii/S2210778917300697 |
en |
pubs.end-page |
154 |
en |
pubs.publication-status |
Published |
en |
dc.rights.accessrights |
http://purl.org/eprint/accessRights/RestrictedAccess |
en |
pubs.subtype |
Article |
en |
pubs.elements-id |
649260 |
en |
pubs.org-id |
Liggins Institute |
en |
pubs.org-id |
Medical and Health Sciences |
en |
pubs.org-id |
Medical Sciences |
en |
pubs.org-id |
Physiology Division |
en |
pubs.org-id |
School of Medicine |
en |
pubs.org-id |
Obstetrics and Gynaecology |
en |
pubs.org-id |
Science |
en |
pubs.org-id |
Statistics |
en |
dc.identifier.eissn |
2210-7797 |
en |
pubs.record-created-at-source-date |
2017-08-16 |
en |
pubs.online-publication-date |
2017-07-27 |
en |
pubs.dimensions-id |
29153669 |
en |