Towards anticancer metal complexes based on hydroxyquinoline-derived ligands

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dc.contributor.advisor Hartinger, C en Kim, Jae en 2018-05-17T03:20:14Z en 2018 en
dc.identifier.uri en
dc.description Full text is available to authenticated members of The University of Auckland only. en
dc.description.abstract Cancer is one of the main causes of death worldwide. According to the World Health Organization (WHO), the number of diagnosed cancer patients is expected to rise by about 70% over the next two decades. Ever since the serendipitous discovery of cisplatin, and as the role of metals in anticancer drugs are studied more in depth, a variety of metal-based anticancer drugs has been synthesized and studied. Out of all the metals, ruthenium-based drugs have been found to exhibit promising anticancer activity. NAMI-A and KP1019 are key examples of ruthenium-based anticancer drugs. A new class of ruthenium derivatives, the "piano-stool" [(η6-arene)Ru(X)(Y)(Z)] complexes, have gained attention as anticancer agents. The arene stabilises RuII and the ligands X, Y, and Z can serves to form either mono, bi, or tridentate ligand to provide better anticancer activity. The quinoline scaffold is found in a large number of natural and commercial products, and its derivatives are constantly being researched. From quinoline derivatives, 8-hydroxyquinoline and its derivatives are widely used as drugs and it exhibits a compelling coordinating ability and good recognition properties to form complexes with divalent metal ions through chelation. Hence it is widely used for analytical and separation purposes as well as for metal chelation. Since an imbalance of metal ions causes numerous health issues, 8-hydroxyquinoline can successfully serve as a potent chelator to restore metal balance to treat metal-related diseases. For this project, 8-hydroxyquinoline and its derivative were synthesised by functionalising the hydroxyl group of 8-hydroxyquinoline with suberic acid which were then complex with the various [MCl2(η6-p-cymene/η5-Cp*)] dimers. These complexes were characterised with 1D and 2D NMR spectroscopy, mass spectrometry and elemental analysis to confirm the structures. Stability studies in DMSO and D2O solvent were also carried out for selected complexes to observe the behaviour during cell viability test. In vitro studies was conducted for selected complexes. Complexes 3a and 3c showed higher in anticancer activity than other complexes. Across the cell lines, all complexes displayed lower in anticancer activity on SiHa cell line. en
dc.publisher ResearchSpace@Auckland en
dc.relation.ispartof Masters Thesis - University of Auckland en
dc.relation.isreferencedby UoA99265061712402091 en
dc.rights Items in ResearchSpace are protected by copyright, with all rights reserved, unless otherwise indicated. Previously published items are made available in accordance with the copyright policy of the publisher. en
dc.rights Restricted Item. Available to authenticated members of The University of Auckland. en
dc.rights.uri en
dc.rights.uri en
dc.title Towards anticancer metal complexes based on hydroxyquinoline-derived ligands en
dc.type Thesis en Chemical Sciences en The University of Auckland en Masters en
dc.rights.holder Copyright: The author en
pubs.elements-id 740402 en
pubs.record-created-at-source-date 2018-05-17 en

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