The Impact of Age on Acute Bioavailability of Minerals from a Multivitamin and Mineral Supplement

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dc.contributor.advisor Cameron-Smith, D en
dc.contributor.advisor Milan, A en Han, Soo en 2018-07-01T23:43:06Z en 2018 en
dc.identifier.uri en
dc.description Full text is available to authenticated members of The University of Auckland only. en
dc.description.abstract Minerals are an essential dietary factor required for metabolic processes; inadequate intakes may lead to increased incidence of chronic disease. Age-associated physiological changes and changes in eating behaviours increase the risk of mineral inadequacy in the elderly. Yet, while mineral intake can be supplemented in the diet, alterations in absorption and use may impact their efficacy. However, the impact of age on supplemental mineral bioavailability has not been clearly identified. Therefore, this study aimed to compare the bioavailability of minerals following consumption of supplemental minerals in old and young adults. Healthy young adults aged 19-30 years and old adults aged 65-76 years (each n=20, 10/10 males/females) consumed one multivitamin and mineral supplement tablet with a breakfast meal. Fasting serum and urine samples were collected prior to the intervention and postprandial samples at hourly intervals for 4 hours. Enzymatic colorimetric assays were used to measure changes in circulating and urinary minerals: calcium, magnesium, phosphate, iron, sodium, chloride and potassium. Following the supplement, serum calcium and magnesium concentrations increased in young adults at 1 hour (all p<0.05), with calcium being greater in the young than in the old adults (p=0.019). By 4 hours, serum calcium and phosphate levels increased in all participants, whereas magnesium and iron increased in the young only. Serum sodium and chloride elevated in all participants at 1 and 4 hours while serum potassium did not change significantly. After 4 hours, renal phosphate concentration was lower in the young (p=0.003) and the percentage changes in sodium (p=0.024) and chloride (p=0.006) excretion were lower in the old. In all subjects, a single supplement dose increased serum and renal mineral concentrations. Older adults have lower responses for serum calcium and magnesium and altered urinary sodium and chloride concentrations. These suggest that age-associated changes in absorption and/or excretion are likely to impact on acute mineral bioavailability in the elderly. Future studies using a wider variety of supplement types, with repeated ingestion and with co-ingestion of food, are required to fully understand the impact that normal ageing exerts on mineral bioavailability. en
dc.publisher ResearchSpace@Auckland en
dc.relation.ispartof Masters Thesis - University of Auckland en
dc.relation.isreferencedby UoA99265067206802091 en
dc.rights Items in ResearchSpace are protected by copyright, with all rights reserved, unless otherwise indicated. Previously published items are made available in accordance with the copyright policy of the publisher. en
dc.rights Restricted Item. Available to authenticated members of The University of Auckland. en
dc.rights.uri en
dc.rights.uri en
dc.title The Impact of Age on Acute Bioavailability of Minerals from a Multivitamin and Mineral Supplement en
dc.type Thesis en Biomedical Science en The University of Auckland en Masters en
dc.rights.holder Copyright: The author en
pubs.elements-id 746681 en
pubs.record-created-at-source-date 2018-07-02 en

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