Automated Techniques for Classification and Quantification of Colonic Manometry

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dc.contributor.advisor Paskaranandavadivel, N en
dc.contributor.advisor Cheng, LK en Mollaee, Saeed en 2018-07-20T03:18:21Z en 2018 en
dc.identifier.uri en
dc.description Available to authenticated members of The University of Auckland. en
dc.description.abstract Novel diagnostics and therapies are emerging in the field of colonic motility. In order to evaluate the effectiveness of these novel therapies, colonic manometry is used to measure the pressure of the colon. Recently, however, clinicians have utilised high-resolution manometry (HRM) due to its capability to record the pressure from all segments of the colon. The advent of HRM has improved experimental and clinical understanding of colonic motility. HRM data has been useful in depicting two notable colonic motor patterns: the cyclic propagation motor pattern (CMP) and high amplitude propagation sequence (HAPS). However, one of the current limitations of HRM is the excessive amount of data, making manual analysis a tedious and time-consuming task. More importantly, manual analysis is prone to observer bias and error, and could result in misconstrued experimental observations. In this study, automated methods have been developed to detect and classify colonic motor patterns. The first step was to pre-process the signal, and a three-step filtering was designed to this end. Several methods such as root mean square and moving average were tested to remove the baseline and smooth the data. The secant method was selected to remove the baseline, the median technique was used to remove the synchronous noise, and Savitzky-Golay filter to smooth the data. Then, an algorithm was developed to detect the HAPS and CMP by analysing the amplitude in each channel to find the peaks and compare them regarding time with the peaks in other channels to form propagation. The precision of the algorithm in detecting the HAPS and CMP was 87% and 91% respectively. Finally, a novel and reliable quantitative method was developed to estimate the velocity, amplitude and the extent of propagation of the colonic motor pattern and to automatically classify the HAPS and CMP into retrograde or antegrade. The classification precision was 91% for HAPS and 72% for CMP. This thesis presents a path forward in the colonic field for the use of quantitative HRM data in clinical diagnosis and prognosis, enabling practitioners to direct treatment strategies accordingly and improve patient care outcomes. en
dc.publisher ResearchSpace@Auckland en
dc.relation.ispartof Masters Thesis - University of Auckland en
dc.relation.isreferencedby UoA99265086814102091 en
dc.rights Items in ResearchSpace are protected by copyright, with all rights reserved, unless otherwise indicated. Previously published items are made available in accordance with the copyright policy of the publisher. en
dc.rights Restricted Item. Available to authenticated members of The University of Auckland. en
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dc.rights.uri en
dc.title Automated Techniques for Classification and Quantification of Colonic Manometry en
dc.type Thesis en Bioengineering en The University of Auckland en Masters en
dc.rights.holder Copyright: The author en
pubs.elements-id 748094 en Engineering en Engineering Science en
pubs.record-created-at-source-date 2018-07-20 en

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