dc.contributor.advisor |
Sharma, M |
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dc.contributor.author |
Chandramouli, K |
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dc.date.accessioned |
2018-09-14T01:49:20Z |
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dc.date.issued |
2018 |
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dc.identifier.uri |
http://hdl.handle.net/2292/37692 |
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dc.description |
Full text is available to authenticated members of The University of Auckland only. |
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dc.description.abstract |
Introduction: Bone fracture causes disability across all ages, bone healing is slow and is associated with high health expenditure costs. Recent studies have shown that lactoferrin can act as a growth factor stimulating bone healing. A localized sustained delivery of lactoferrin would be beneficial in promoting the bone healing process. Currently not many efficient drug delivery systems for lactoferrin are reported. Poloxamers are a class of smart polymers which can act as vehicles for controlled drug delivery. They are liquid at room temperature and form an in-situ gel depot when injected into a biological system (thermoreversible). The main aim of the thesis was to develop a thermoresponsive poloxamers based in-situ gelling formulation loaded with therapeutic concentrations of lactoferrin with the ability to provide sustained release of lactoferrin for a period of up to three days and enhance the bone healing process. with the ability to provide sustained release of lactoferrin for a period of up to three days and enhance the bone healing process. |
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dc.publisher |
ResearchSpace@Auckland |
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dc.relation.ispartof |
Masters Thesis - University of Auckland |
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dc.relation.isreferencedby |
UoA99265077214102091 |
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dc.rights |
Items in ResearchSpace are protected by copyright, with all rights reserved, unless otherwise indicated. Previously published items are made available in accordance with the copyright policy of the publisher. |
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dc.rights |
Restricted Item. Available to authenticated members of The University of Auckland. |
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dc.rights.uri |
https://researchspace.auckland.ac.nz/docs/uoa-docs/rights.htm |
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dc.rights.uri |
http://creativecommons.org/licenses/by-nc-sa/3.0/nz/ |
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dc.title |
Injectable Thermo-gelling Delivery System for Lactoferrin: In-vitro and In-vivo Evaluation |
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dc.type |
Thesis |
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thesis.degree.discipline |
Health Sciences |
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thesis.degree.grantor |
The University of Auckland |
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thesis.degree.level |
Masters |
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dc.rights.holder |
Copyright: The author |
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pubs.elements-id |
753095 |
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pubs.record-created-at-source-date |
2018-09-14 |
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dc.identifier.wikidata |
Q112935892 |
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