Birds and longevity: Does flight driven aerobicity provide an oxidative sink?

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dc.contributor.author Hickey, Anthony en
dc.contributor.author Jüllig, M en
dc.contributor.author Aitken, Jacqueline en
dc.contributor.author Loomes, Kerry en
dc.contributor.author Hauber, M en
dc.contributor.author Phillips, Anthony en
dc.date.accessioned 2012-05-09T21:09:50Z en
dc.date.accessioned 2018-10-01T01:32:29Z en
dc.date.issued 2012-04 en
dc.identifier.citation Ageing Research Reviews 11(2):242-253 Apr 2012 en
dc.identifier.issn 1568-1637 en
dc.identifier.uri http://hdl.handle.net/2292/37828 en
dc.description.abstract Birds generally age slower and live longer than similar sized mammals. For birds this occurs despite elevated blood glucose levels that for mammals would in part define them as diabetic. However these data were acquired in respiration states that have little resemblance to conditions in healthy tissues and mitochondrial RS production is probably minimal in healthy animals. Indeed mitochondria probably act as net consumers rather than producers of RS. Here we propose that (1) if mitochondria are antioxidant systems, the greater mitochondrial mass in athletic species, such as birds, is advantageous as it should provide a substantial sink for RS. (2) The intense drive for aerobic performance and decreased body density to facilitate flight may explain the relative insensitivity of birds to insulin, as well as depressed insulin levels and apparent sensitization to glucagon. Glucagon also associates with the sirtuin protein family, most of which are associated with caloric restriction regulated pathways, mitochondrial biogenesis and life span extension. (3) We note that telomeres, which appear to be unusually long in birds, bind Sirtuins 2 and 4 and therefore may stabilize and protect nuclear DNA. Ultimately these flight driven responses may suppress somatic growth and protect DNA from oxidative damage that would otherwise lead to ageing and non-viral cancers. en
dc.publisher Elsevier Masson en
dc.relation.ispartofseries Ageing Research Reviews en
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dc.rights Items in ResearchSpace are protected by copyright, with all rights reserved, unless otherwise indicated. Previously published items are made available in accordance with the copyright policy of the publisher. Details obtained from http://www.sherpa.ac.uk/romeo/issn/1568-1637/ en
dc.rights.uri https://researchspace.auckland.ac.nz/docs/uoa-docs/rights.htm en
dc.title Birds and longevity: Does flight driven aerobicity provide an oxidative sink? en
dc.type Journal Article en
dc.identifier.doi 10.1016/j.arr.2011.12.002 en
pubs.issue 2 en
pubs.begin-page 242 en
pubs.volume 11 en
dc.rights.holder Copyright: Elsevier Masson en
dc.identifier.pmid 22198369 en
pubs.end-page 253 en
pubs.merge-from 2292/16022 en
pubs.merge-from http://hdl.handle.net/2292/16022 en
dc.rights.accessrights http://purl.org/eprint/accessRights/RestrictedAccess en
pubs.subtype Article en
pubs.elements-id 261244 en
pubs.org-id Science en
pubs.org-id Biological Sciences en
pubs.org-id Science Research en
pubs.org-id Maurice Wilkins Centre (2010-2014) en
pubs.record-created-at-source-date 2011-12-15 en
pubs.dimensions-id 22198369 en


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