dc.contributor.author |
Reade, Michael C |
en |
dc.contributor.author |
Delaney, Anthony |
en |
dc.contributor.author |
Bailey, Michael J |
en |
dc.contributor.author |
Harrison, David A |
en |
dc.contributor.author |
Yealy, Donald M |
en |
dc.contributor.author |
Jones, Peter |
en |
dc.contributor.author |
Rowan, Kathryn M |
en |
dc.contributor.author |
Bellomo, Rinaldo |
en |
dc.contributor.author |
Angus, Derek C |
en |
dc.date.accessioned |
2018-10-02T03:16:14Z |
en |
dc.date.issued |
2010-01 |
en |
dc.identifier.issn |
0342-4642 |
en |
dc.identifier.uri |
http://hdl.handle.net/2292/38208 |
en |
dc.description.abstract |
Meta-analysis is a technique for combining evidence from multiple trials. However, meta-analyses of studies with substantial heterogeneity among patients within trials-common in intensive care-can lead to incorrect conclusions if performed using aggregate data. Use of individual patient data (IPD) can avoid this concern, increase the power of a meta-analysis, and is useful for exploring subgroup effects. Barriers exist to IPD meta-analysis, most of which are overcome if clinical trials are designed to prospectively facilitate the incorporation of their results with other trials. We review the features of prospective IPD meta-analysis and identify those of relevance to intensive care research. We identify three clinical questions, which are the subject of recent or planned randomised controlled trials where IPD MA offers advantages over approaches using aggregate data. |
en |
dc.format.medium |
Print-Electronic |
en |
dc.language |
eng |
en |
dc.relation.ispartofseries |
Intensive care medicine |
en |
dc.rights |
Items in ResearchSpace are protected by copyright, with all rights reserved, unless otherwise indicated. Previously published items are made available in accordance with the copyright policy of the publisher. |
en |
dc.rights.uri |
https://researchspace.auckland.ac.nz/docs/uoa-docs/rights.htm |
en |
dc.subject |
Humans |
en |
dc.subject |
Critical Care |
en |
dc.subject |
Medical Records |
en |
dc.subject |
Data Interpretation, Statistical |
en |
dc.subject |
Prospective Studies |
en |
dc.subject |
Patients |
en |
dc.subject |
Meta-Analysis as Topic |
en |
dc.subject |
Outcome Assessment, Health Care |
en |
dc.title |
Prospective meta-analysis using individual patient data in intensive care medicine. |
en |
dc.type |
Journal Article |
en |
dc.identifier.doi |
10.1007/s00134-009-1650-x |
en |
pubs.issue |
1 |
en |
pubs.begin-page |
11 |
en |
pubs.volume |
36 |
en |
dc.rights.holder |
Copyright: The author |
en |
pubs.end-page |
21 |
en |
pubs.publication-status |
Published |
en |
dc.rights.accessrights |
http://purl.org/eprint/accessRights/RestrictedAccess |
en |
pubs.subtype |
Research Support, Non-U.S. Gov't |
en |
pubs.subtype |
research-article |
en |
pubs.subtype |
Journal Article |
en |
pubs.subtype |
Research Support, N.I.H., Extramural |
en |
pubs.elements-id |
685111 |
en |
pubs.org-id |
Medical and Health Sciences |
en |
pubs.org-id |
School of Medicine |
en |
pubs.org-id |
Surgery Department |
en |
dc.identifier.eissn |
1432-1238 |
en |
pubs.record-created-at-source-date |
2009-09-18 |
en |
pubs.dimensions-id |
19760395 |
en |