dc.contributor.author |
Coutey, C |
en |
dc.contributor.author |
Berg, M |
en |
dc.contributor.author |
Ho, Harvey |
en |
dc.contributor.author |
Hunter, Peter |
en |
dc.date.accessioned |
2018-10-04T23:27:39Z |
en |
dc.date.issued |
2016-01-01 |
en |
dc.identifier.isbn |
9783319283272 |
en |
dc.identifier.uri |
http://hdl.handle.net/2292/38980 |
en |
dc.description.abstract |
© Springer International Publishing Switzerland 2016. When the blood flow is considered as steady Poiseuille flow, the governing Navier-Stokes equations can be reduced to the Hagen-Poiseuille law. This simplification results in a substantially reduced computational cost which is very useful in real-time blood flow simulations, in particular for large vasculatures containing thousands of blood vessels. By incorporating a convection equation we can also simulate transient drug transportation in the vasculature. In this paper we present at first the implementation of a real-time flow solver which is coupled with a complex arterial tree generated from the Constrained Constructive Optimisation (CCO) algorithm. The computational time for ~ 8200 vessels was 0.2s. Secondly, we simulate the transient drug transportation in the vasculature. Thirdly, we model the delivery of the drug into a tiny tissue block by adopting a 3D diffusion equation. In conclusion the presented computational techniques constitute a pipeline for circulation modelling in multiple scales, and may be used in a variety of biomedical applications. |
en |
dc.relation.ispartof |
Computational Biomechanics for Medicine: Imaging, Modeling and Computing |
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dc.rights |
Items in ResearchSpace are protected by copyright, with all rights reserved, unless otherwise indicated. Previously published items are made available in accordance with the copyright policy of the publisher. |
en |
dc.rights.uri |
https://researchspace.auckland.ac.nz/docs/uoa-docs/rights.htm |
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dc.title |
Computational simulation of blood flow and drug transportation in a large vasculature |
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dc.type |
Book Item |
en |
dc.identifier.doi |
10.1007/978-3-319-28329-6_12 |
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pubs.begin-page |
133 |
en |
dc.rights.holder |
Copyright: The author |
en |
pubs.end-page |
142 |
en |
pubs.publication-status |
Published |
en |
dc.rights.accessrights |
http://purl.org/eprint/accessRights/RestrictedAccess |
en |
pubs.elements-id |
623252 |
en |
pubs.org-id |
Bioengineering Institute |
en |
pubs.org-id |
ABI Associates |
en |
pubs.org-id |
Science |
en |
pubs.org-id |
Science Research |
en |
pubs.org-id |
Maurice Wilkins Centre (2010-2014) |
en |