Ex-vivo Drug Diffusion and Penetration Models for Ocular Drug Delivery

Abstract

While the eye is readily accessible from the outside of the body, it is a rather isolated organ with a number of barriers and elimination mechanisms in place to protect it from the environment, rendering efficient treatment difficult. To enhance drug bioavailability in the eye, a number of delivery approaches have been investigated over recent decades, increasing drug retention and permeation while also allowing for sustained drug release over prolonged periods. This presentation will give an overview of the various models used to test novel ocular delivery approaches.