Presence of metalloestrogens in ectopic endometrial tissue

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dc.contributor.author Silva, N en
dc.contributor.author Senanayake, H en
dc.contributor.author Peiris-John, Roshini en
dc.contributor.author Wickremasinghe, AR en
dc.contributor.author Sathiakumar, N en
dc.contributor.author Waduge, V en
dc.date.accessioned 2018-10-08T19:28:18Z en
dc.date.issued 2012 en
dc.identifier.uri http://hdl.handle.net/2292/39467 en
dc.description.abstract Background: Heavy metals with estrogenic effects are termed as metalloestrogens which are implicated in the etiology of endometriosis; an estrogen dependent disease. Aim: To demonstrate the presence of metalloestrogens in ectopic endometrial tissue. Settings: A gynaecology unit of a tertiary care hospital and two national level laboratories. Design: Descriptive study Methods: In fifty patients with endometriosis confirmed by laparoscopy or laparotomy, ectopic endometrial tissue samples (n=50) were collected. Tissue samples were digested using supra pure 65% HNO3 and levels of metalloestrogens were measured using Total Reflection X-ray Fluorescence (TXRF) and graphite furnace atomic absorption spectroscopy (GFASS). Results: Three metalloestrogens, namely cadmium, nickel and lead were detected in the ectopic endometrial tissue with geometric mean (95% CI) levels of 2.861 (2.126-3.596), 17.547(13.152-21.942) and 25.785(18.490-33.080) μg/Kg respectively. Conclusion: In this study, metalloestrogens viz. cadmium, nickel and lead were present in the ectopic endometrial tissue. en
dc.relation.ispartofseries Journal of Pharmaceutical and Biomedical Sciences en
dc.rights Items in ResearchSpace are protected by copyright, with all rights reserved, unless otherwise indicated. Previously published items are made available in accordance with the copyright policy of the publisher. en
dc.rights.uri https://researchspace.auckland.ac.nz/docs/uoa-docs/rights.htm en
dc.title Presence of metalloestrogens in ectopic endometrial tissue en
dc.type Journal Article en
pubs.issue 24 en
pubs.begin-page 1 en
pubs.volume 24 en
pubs.end-page 5 en
dc.rights.accessrights http://purl.org/eprint/accessRights/RestrictedAccess en
pubs.subtype Article en
pubs.elements-id 407203 en
pubs.org-id Faculty of Medical & Hlth Sci en
pubs.org-id Population Health en
pubs.org-id Epidemiology & Biostatistics en
dc.identifier.eissn 2230-7885 en
pubs.record-created-at-source-date 2013-10-08 en


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