dc.contributor.author |
Kalev, Maggie |
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dc.coverage.spatial |
University of Zurich, Zurich Center for Integrative Human Physiology |
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dc.date.accessioned |
2018-10-08T22:40:23Z |
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dc.date.issued |
2017-08-28 |
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dc.identifier.uri |
http://hdl.handle.net/2292/39607 |
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dc.description.abstract |
Mutations in a calcium binding protein called Calreticulin are present in approximately 30% of human patients with certain chronic megakaryocytic cancers; however, their role in cancer development remains unclear. Our lab examines calcium pathways in megakaryocytes and platelets to elucidate mechanisms of disease development. We often modulate glutamate-activated NMDA receptors that have been under-studied in these cells but good drug targets. This seminar will present some of our most recent results indicating that calcium influx facilitates maturation of normal megakaryocytes but the same pathway is subverted in leukaemic cells to increase proliferation. Inhibition of calcium influx through the receptor redirects leukaemic cells into differentiation, suggesting potential for therapeutic modulation that warrants further testing. We are now planning a patient study to determine patterns of calcium deregulation associated with pre-malignant and malignant platelet precursor disorders. |
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dc.relation.ispartof |
Invited Research Visit at the University of Zurich |
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dc.rights |
Items in ResearchSpace are protected by copyright, with all rights reserved, unless otherwise indicated. Previously published items are made available in accordance with the copyright policy of the publisher. |
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dc.rights.uri |
https://researchspace.auckland.ac.nz/docs/uoa-docs/rights.htm |
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dc.title |
Deregulated calcium pathways in platelet precursor cancers |
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dc.type |
Presentation |
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dc.rights.holder |
Copyright: The author |
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dc.rights.accessrights |
http://purl.org/eprint/accessRights/RestrictedAccess |
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pubs.subtype |
Invited |
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pubs.elements-id |
663483 |
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pubs.org-id |
Medical and Health Sciences |
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pubs.org-id |
Medical Sciences |
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pubs.org-id |
Molecular Medicine |
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pubs.record-created-at-source-date |
2017-09-11 |
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