Does mesenteric lymph promote or inhibit bacterial growth?

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Show simple item record Loveday, Benjamin en Brown, L en Swift, Simon en Mittal, A en Windsor, John en Phillips, Anthony en
dc.coverage.spatial Southampton, UK en 2018-10-09T23:09:53Z en 2014-06 en
dc.identifier.issn 1424-3903 en
dc.identifier.uri en
dc.description.abstract Background : In severe acute pancreatitis the pancreas can become infected. Lymph can act as a conduit for bacteria from the intestine. Mesenteric lymph (ML) changes dramatically in composition during acute disease states. It is unknown whether these changes inhibit or promote bacterial growth. Aims : The aim of this study was to determine the effect of acute and chronic disease-conditioned ML on bacterial growth. Materials & methods : ML was sourced from four animal models (n = 5 per group): i) Acute Pancreatitis [AP], ii) Hemorrhagic Shock [HS], iii) Diabetes Mellitus [DM] and iv) Control [C] (normal lymph). Five bacterial species were studied: E.coli, S. aureus, K. pneumoniae, E.faecalis, and P. oxytoca . Bacteria were seeded as low and high concentration inoculums into the ML, and bacterial growth measured after incubation for 4 and 24 hours. Results : In all ML groups, after a low concentration innoculation, the concentration of S. aureus , E.faecalis , and P. oxytoca increased, while E. coli and K. pneumoniae were inhibited by control lymph. After a high concentration inoculation, bacterial growth was promoted in all disease conditioned ML, except that DM- and AP-conditioned ML inhibited the growth of S. aureus and E. fecalis . HS conditioned ML promoted the growth of all bacteria types at both low and high concentration inoculations. Conclusion : There was a complex interaction between bacterial species, inoculum concentration, and disease state. Disease conditioned ML does not consistently inhibit or promote the growth of translocating bacteria. Further research will be required to develop strategies to prevent or treat bacteria in ML during severe illness. en
dc.description.uri en
dc.publisher Elsevier en
dc.relation.ispartof 2014 Combined European Pancreatic Club and International Association of Pancreatology Annual Meeting en
dc.rights Items in ResearchSpace are protected by copyright, with all rights reserved, unless otherwise indicated. Previously published items are made available in accordance with the copyright policy of the publisher. en
dc.rights.uri en
dc.title Does mesenteric lymph promote or inhibit bacterial growth? en
dc.type Conference Item en
pubs.issue 3, S1 en
pubs.begin-page S11 en
pubs.volume 14 en
dc.rights.holder Copyright: The author en
pubs.end-page S11 en
pubs.finish-date 2014-06-28 en
pubs.start-date 2014-06-24 en
dc.rights.accessrights en
pubs.subtype Abstract en
pubs.elements-id 721670 en Medical and Health Sciences en Medical Sciences en Molecular Medicine en School of Medicine en Surgery Department en Science en Biological Sciences en Science Research en Maurice Wilkins Centre (2010-2014) en
dc.identifier.eissn 1424-3911 en
pubs.record-created-at-source-date 2018-01-19 en

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