Neuroprotection with Glycine-2-methylproline-Glutamate (G-2MePE) after hypoxic-ischemic brain injury in adult rats

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dc.contributor.author Mathai, Sam en
dc.contributor.author Harris, Paul en
dc.contributor.author Brimble, Margaret en
dc.contributor.author Gunn, Alistair en
dc.contributor.author Guan, Jian en
dc.date.accessioned 2018-10-10T00:11:22Z en
dc.date.issued 2014-12-09 en
dc.identifier.citation Journal of Experimental Stroke and Translational Medicine 6: 09 Dec 2014 en
dc.identifier.issn 1939-067X en
dc.identifier.uri http://hdl.handle.net/2292/40165 en
dc.description.abstract Background and Purpose: Hypoxic -ischemic brain injury, due to reduced supply of oxygen, is a major cause of death and disability. There is no exclusive treatment available so far. Glycine-2-Methylproline-Glutamate(G-2MePE, NNZ 2566) , an analogue of Glycine-Proline-Glutamate reduces neuronal injury after focal ischemia in adult rats. The current study investigated into the neuroprotective effects of G-2MePE (1.2mg/kg) 3h post hypoxic-ischemic brain injury or the same volume of normal saline. Brains were extracted 5 days after the treatment. Tissue damage in the cortex, hippocampus and striatum was assessed. Neuronal survival, glial reactions, caspase-3 activity and TNF-a cytokine activity were also assessed. Results: The treatment with G-2Me-PE was associated with a significant reduction of tissue damage, improvement in neuronal survival, reduction in reactive microglia, TNF-a positive cells and caspase-3 positive cells in hippocampus and cortex but an elevation of astrocytosis. Conclusion: Neuroprotection with G-2MePE after hypoxic -ischemic brain injury in adult rats is associated with reduced neuronal necrosis, apoptosis, modulated inflammatory response and augmented astrocytosis. en
dc.publisher Society for Experimental Stroke en
dc.relation.ispartofseries Journal of Experimental Stroke and Translational Medicine en
dc.rights Items in ResearchSpace are protected by copyright, with all rights reserved, unless otherwise indicated. Previously published items are made available in accordance with the copyright policy of the publisher. en
dc.rights.uri https://researchspace.auckland.ac.nz/docs/uoa-docs/rights.htm en
dc.rights.uri https://creativecommons.org/licenses/by-nc/3.0/ en
dc.title Neuroprotection with Glycine-2-methylproline-Glutamate (G-2MePE) after hypoxic-ischemic brain injury in adult rats en
dc.type Journal Article en
pubs.begin-page 1 en
pubs.volume 6 en
dc.rights.holder Copyright: Society for Experimental Stroke en
pubs.author-url http://www.jestm.com/open-access/neuroprotection-with-glycine2methylprolineglutamate-g2mepe-after-hypoxicischemic-brain-injury-inadult-rats-.pdf en
pubs.end-page 11 en
dc.rights.accessrights http://purl.org/eprint/accessRights/OpenAccess en
pubs.subtype Article en
pubs.elements-id 489819 en
pubs.org-id Medical and Health Sciences en
pubs.org-id Medical Sciences en
pubs.org-id Pharmacology en
pubs.org-id Physiology Division en
pubs.org-id Science en
pubs.org-id Biological Sciences en
pubs.org-id Chemistry en
pubs.org-id Science Research en
pubs.org-id Maurice Wilkins Centre (2010-2014) en
pubs.record-created-at-source-date 2015-07-09 en


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https://creativecommons.org/licenses/by-nc/3.0/ Except where otherwise noted, this item's license is described as https://creativecommons.org/licenses/by-nc/3.0/

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