dc.contributor.author |
Mathai, Sam |
en |
dc.contributor.author |
Harris, Paul |
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dc.contributor.author |
Brimble, Margaret |
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dc.contributor.author |
Gunn, Alistair |
en |
dc.contributor.author |
Guan, Jian |
en |
dc.date.accessioned |
2018-10-10T00:11:22Z |
en |
dc.date.issued |
2014-12-09 |
en |
dc.identifier.citation |
Journal of Experimental Stroke and Translational Medicine 6: 09 Dec 2014 |
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dc.identifier.issn |
1939-067X |
en |
dc.identifier.uri |
http://hdl.handle.net/2292/40165 |
en |
dc.description.abstract |
Background and Purpose: Hypoxic -ischemic brain injury, due to reduced supply of oxygen, is a major cause of death and disability. There is no exclusive treatment available so far. Glycine-2-Methylproline-Glutamate(G-2MePE, NNZ 2566) , an analogue of Glycine-Proline-Glutamate reduces neuronal injury after focal ischemia in adult rats. The current study investigated into the neuroprotective effects of G-2MePE (1.2mg/kg) 3h post hypoxic-ischemic brain injury or the same volume of normal saline. Brains were extracted 5 days after the treatment. Tissue damage in the cortex, hippocampus and striatum was assessed. Neuronal survival, glial reactions, caspase-3 activity and TNF-a cytokine activity were also assessed. Results: The treatment with G-2Me-PE was associated with a significant reduction of tissue damage, improvement in neuronal survival, reduction in reactive microglia, TNF-a positive cells and caspase-3 positive cells in hippocampus and cortex but an elevation of astrocytosis. Conclusion: Neuroprotection with G-2MePE after hypoxic -ischemic brain injury in adult rats is associated with reduced neuronal necrosis, apoptosis, modulated inflammatory response and augmented astrocytosis. |
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dc.publisher |
Society for Experimental Stroke |
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dc.relation.ispartofseries |
Journal of Experimental Stroke and Translational Medicine |
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dc.rights |
Items in ResearchSpace are protected by copyright, with all rights reserved, unless otherwise indicated. Previously published items are made available in accordance with the copyright policy of the publisher. |
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dc.rights.uri |
https://researchspace.auckland.ac.nz/docs/uoa-docs/rights.htm |
en |
dc.rights.uri |
https://creativecommons.org/licenses/by-nc/3.0/ |
en |
dc.title |
Neuroprotection with Glycine-2-methylproline-Glutamate (G-2MePE) after hypoxic-ischemic brain injury in adult rats |
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dc.type |
Journal Article |
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pubs.begin-page |
1 |
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pubs.volume |
6 |
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dc.rights.holder |
Copyright: Society for Experimental Stroke |
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pubs.author-url |
http://www.jestm.com/open-access/neuroprotection-with-glycine2methylprolineglutamate-g2mepe-after-hypoxicischemic-brain-injury-inadult-rats-.pdf |
en |
pubs.end-page |
11 |
en |
dc.rights.accessrights |
http://purl.org/eprint/accessRights/OpenAccess |
en |
pubs.subtype |
Article |
en |
pubs.elements-id |
489819 |
en |
pubs.org-id |
Medical and Health Sciences |
en |
pubs.org-id |
Medical Sciences |
en |
pubs.org-id |
Pharmacology |
en |
pubs.org-id |
Physiology Division |
en |
pubs.org-id |
Science |
en |
pubs.org-id |
Biological Sciences |
en |
pubs.org-id |
Chemistry |
en |
pubs.org-id |
Science Research |
en |
pubs.org-id |
Maurice Wilkins Centre (2010-2014) |
en |
pubs.record-created-at-source-date |
2015-07-09 |
en |