dc.contributor.author |
Muehe, Anne M |
en |
dc.contributor.author |
Theruvath, Ashok J |
en |
dc.contributor.author |
Lai, Lillian |
en |
dc.contributor.author |
Aghighi, Maryam |
en |
dc.contributor.author |
Quon, Andrew |
en |
dc.contributor.author |
Holdsworth, Samantha |
en |
dc.contributor.author |
Wang, Jia |
en |
dc.contributor.author |
Luna-Fineman, Sandra |
en |
dc.contributor.author |
Marina, Neyssa |
en |
dc.contributor.author |
Advani, Ranjana |
en |
dc.contributor.author |
Rosenberg, Jarrett |
en |
dc.contributor.author |
Daldrup-Link, Heike E |
en |
dc.date.accessioned |
2018-10-10T22:44:38Z |
en |
dc.date.issued |
2018-04 |
en |
dc.identifier.issn |
1536-1632 |
en |
dc.identifier.uri |
http://hdl.handle.net/2292/40587 |
en |
dc.description.abstract |
PURPOSE:To provide clinically useful gadolinium-free whole-body cancer staging of children and young adults with integrated positron emission tomography/magnetic resonance (PET/MR) imaging in less than 1 h. PROCEDURES:In this prospective clinical trial, 20 children and young adults (11-30 years old, 6 male, 14 female) with solid tumors underwent 2-deoxy-2-[18F]fluoro-D-glucose ([18F]FDG) PET/MR on a 3T PET/MR scanner after intravenous injection of ferumoxytol (5 mg Fe/kg) and [18F]FDG (2-3 MBq/kg). Time needed for patient preparation, PET/MR image acquisition, and data processing was compared before (n = 5) and after (n = 15) time-saving interventions, using a Wilcoxon test. The ferumoxytol-enhanced PET/MR images were compared with clinical standard staging tests regarding radiation exposure and tumor staging results, using Fisher's exact tests. RESULTS:Tailored workflows significantly reduced scan times from 36 to 24 min for head to mid thigh scans (p < 0.001). These streamlined PET/MR scans were obtained with significantly reduced radiation exposure (mean 3.4 mSv) compared to PET/CT with diagnostic CT (mean 13.1 mSv; p = 0.003). Using the iron supplement ferumoxytol "off label" as an MR contrast agent avoided gadolinium chelate administration. The ferumoxytol-enhanced PET/MR scans provided equal or superior tumor staging results compared to clinical standard tests in 17 out of 20 patients. Compared to PET/CT, PET/MR had comparable detection rates for pulmonary nodules with diameters of equal or greater than 5 mm (94 vs. 100 %), yet detected significantly fewer nodules with diameters of less than 5 mm (20 vs 100 %) (p = 0.03). [18F]FDG-avid nodules were detected with slightly higher sensitivity on the PET of the PET/MR compared to the PET of the PET/CT (59 vs 49 %). CONCLUSION:Our streamlined ferumoxytol-enhanced PET/MR protocol provided cancer staging of children and young adults in less than 1 h with equivalent or superior clinical information compared to clinical standard staging tests. The detection of small pulmonary nodules with PET/MR needs to be improved. |
en |
dc.format.medium |
Print |
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dc.language |
eng |
en |
dc.relation.ispartofseries |
Molecular imaging and biology |
en |
dc.rights |
Items in ResearchSpace are protected by copyright, with all rights reserved, unless otherwise indicated. Previously published items are made available in accordance with the copyright policy of the publisher. |
en |
dc.rights.uri |
https://researchspace.auckland.ac.nz/docs/uoa-docs/rights.htm |
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dc.subject |
Humans |
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dc.subject |
Neoplasms |
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dc.subject |
Lung Neoplasms |
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dc.subject |
Gadolinium |
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dc.subject |
Tomography, X-Ray Computed |
en |
dc.subject |
Magnetic Resonance Imaging |
en |
dc.subject |
Neoplasm Staging |
en |
dc.subject |
Adolescent |
en |
dc.subject |
Adult |
en |
dc.subject |
Child |
en |
dc.subject |
Young Adult |
en |
dc.subject |
Multimodal Imaging |
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dc.subject |
Positron Emission Tomography Computed Tomography |
en |
dc.title |
How to Provide Gadolinium-Free PET/MR Cancer Staging of Children and Young Adults in Less than 1 h: the Stanford Approach. |
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dc.type |
Journal Article |
en |
dc.identifier.doi |
10.1007/s11307-017-1105-7 |
en |
pubs.issue |
2 |
en |
pubs.begin-page |
324 |
en |
pubs.volume |
20 |
en |
dc.rights.holder |
Copyright: The author |
en |
dc.identifier.pmid |
28721605 |
en |
pubs.end-page |
335 |
en |
pubs.publication-status |
Published |
en |
dc.rights.accessrights |
http://purl.org/eprint/accessRights/RestrictedAccess |
en |
pubs.subtype |
research-article |
en |
pubs.subtype |
Journal Article |
en |
pubs.subtype |
Research Support, N.I.H., Extramural |
en |
pubs.elements-id |
683312 |
en |
pubs.org-id |
Medical and Health Sciences |
en |
pubs.org-id |
Medical Sciences |
en |
pubs.org-id |
Anatomy and Medical Imaging |
en |
dc.identifier.eissn |
1860-2002 |
en |
pubs.record-created-at-source-date |
2017-07-20 |
en |
pubs.dimensions-id |
28721605 |
en |