Biotinylated-lipid bilayer coated mesoporous silica nanoparticles for improving the bioavailability and anti-leukaemia activity of Tanshinone IIA.

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dc.contributor.author Li, Zhe en
dc.contributor.author Zhang, Yongtai en
dc.contributor.author Zhang, Kai en
dc.contributor.author Wu, Zimei en
dc.contributor.author Feng, Nianping en
dc.date.accessioned 2018-10-11T02:45:21Z en
dc.date.issued 2018-01-29 en
dc.identifier.issn 2169-1401 en
dc.identifier.uri http://hdl.handle.net/2292/40786 en
dc.description.abstract The oral bioavailability and anti-leukaemia activity of Tanshinone IIA (TanIIA) were enhanced by using biotinylated-lipid bilayer coated mesoporous silica nanoparticles (Bio-LB-MSNs) as a vehicle. The in vitro release of TanIIA from TanIIA@MSNs was significantly higher than that of the TanIIA powder (p < .05). The in vitro cellular uptake of TanIIA by Caco-2 was increased by loading drug into the Bio-LB-MSNs more than those of the compared nanovehicles without biotin modification. The apparent in situ permeability coefficient (Papp) of TanIIA@Bio-LB-MSNs showed nearly 2.5-, 1.6- and 1.3-fold improvement compared with the TanIIA powder, TanIIA@MSNs and TanIIA@LB-MSNs. Following oral administration of TanIIA@Bio-LB-MSNs in rats, the area under the plasma concentration-time curves (AUC) of TanIIA was 3.4-, 1.9- and 2.4-fold larger than those in the groups received a pure TanIIA powder, TanIIA@MSNs or TanIIA@LB-MSNs, indicating that drug bioavailability was enhanced by using MSNs as a vehicle, and further improved significantly through biotin modification. The in vitro anti-leukaemia activity of TanIIA was also enhanced after being loaded into nanoparticles and modification, with 50% inhibitive concentration (IC50) of NB4 cells at 6.5 μM for TanIIA@Bio-LB-MSN. In conclusion, Bio-LB-MSNs are a promising vehicle to improve the oral bioavailability and anti-leukaemia activity of the poorly water-soluble drug TanIIA. en
dc.format.medium Print-Electronic en
dc.language eng en
dc.relation.ispartofseries Artificial cells, nanomedicine, and biotechnology en
dc.rights Items in ResearchSpace are protected by copyright, with all rights reserved, unless otherwise indicated. Previously published items are made available in accordance with the copyright policy of the publisher. en
dc.rights.uri https://researchspace.auckland.ac.nz/docs/uoa-docs/rights.htm en
dc.subject Caco-2 Cells en
dc.subject Animals en
dc.subject Humans en
dc.subject Rats en
dc.subject Leukemia en
dc.subject Silicon Dioxide en
dc.subject Diterpenes, Abietane en
dc.subject Lipid Bilayers en
dc.subject Antineoplastic Agents en
dc.subject Drug Carriers en
dc.subject Biotinylation en
dc.subject Cell Survival en
dc.subject Biological Transport en
dc.subject Biological Availability en
dc.subject Porosity en
dc.subject Nanoparticles en
dc.subject Drug Liberation en
dc.title Biotinylated-lipid bilayer coated mesoporous silica nanoparticles for improving the bioavailability and anti-leukaemia activity of Tanshinone IIA. en
dc.type Journal Article en
dc.identifier.doi 10.1080/21691401.2018.1431651 en
pubs.issue sup1 en
pubs.begin-page 578 en
pubs.volume 46 en
dc.rights.holder Copyright: The author en
dc.identifier.pmid 29374971 en
pubs.end-page 587 en
pubs.publication-status Published en
dc.rights.accessrights http://purl.org/eprint/accessRights/RestrictedAccess en
pubs.subtype Journal Article en
pubs.elements-id 723007 en
pubs.org-id Medical and Health Sciences en
pubs.org-id Pharmacy en
dc.identifier.eissn 2169-141X en
pubs.record-created-at-source-date 2018-01-30 en
pubs.dimensions-id 29374971 en


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