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| dc.contributor.author | Dimitrov, Ivaylo | en |
| dc.contributor.author | Furkert, Daniel | en |
| dc.contributor.author | Fraser, John | en |
| dc.contributor.author | Radcliff, Fiona | en |
| dc.contributor.author | Finch, O | en |
| dc.contributor.author | Brimble, Margaret | en |
| dc.date.accessioned | 2018-10-11T03:05:39Z | en |
| dc.date.issued | 2011 | en |
| dc.identifier.issn | 2040-2503 | en |
| dc.identifier.uri | http://hdl.handle.net/2292/40828 | en |
| dc.description.abstract | Helicobacter pylori affects a significant proportion of the human population. It is the primary agent responsible for gastric and duodenal ulcers and has been further linked with gastric cancer and mucosa-associated lymphoid tissue (MALT lymphoma). Eradication of H. pylori can cure these diseases; however the current therapies used are far from ideal. (+)-Spirolaxine methyl ether (2) exhibits potent activity against H. pylori and is therefore a promising drug candidate. Herein we report the synthesis of eight analogues of spirolaxine methyl ether (2), as well as their anti-H. pylori activity. | en |
| dc.publisher | The Royal Society of Chemistry | en |
| dc.relation.ispartofseries | MedChemComm | en |
| dc.rights | Items in ResearchSpace are protected by copyright, with all rights reserved, unless otherwise indicated. Previously published items are made available in accordance with the copyright policy of the publisher. | en |
| dc.rights.uri | https://researchspace.auckland.ac.nz/docs/uoa-docs/rights.htm | en |
| dc.title | Synthesis and anti-Helicobacter pylori activity of analogues of spirolaxine methyl ether | en |
| dc.type | Journal Article | en |
| dc.identifier.doi | 10.1039/c2md00314g | en |
| pubs.issue | 8 | en |
| pubs.begin-page | 944 | en |
| pubs.volume | 3 | en |
| dc.rights.holder | Copyright: The author | en |
| pubs.end-page | 949 | en |
| dc.rights.accessrights | http://purl.org/eprint/accessRights/RestrictedAccess | en |
| pubs.subtype | Article | en |
| pubs.elements-id | 408002 | en |
| pubs.org-id | Medical and Health Sciences | en |
| pubs.org-id | Medical Sciences | en |
| pubs.org-id | Auckland Cancer Research | en |
| pubs.org-id | Molecular Medicine | en |
| pubs.org-id | Science | en |
| pubs.org-id | Chemistry | en |
| pubs.org-id | Science Research | en |
| pubs.org-id | Maurice Wilkins Centre (2010-2014) | en |
| pubs.record-created-at-source-date | 2012-01-23 | en |
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