dc.contributor.author |
Burrowes, Kelly |
en |
dc.contributor.author |
Iravani, Amin |
en |
dc.contributor.author |
Kang, Wenying |
en |
dc.date.accessioned |
2018-10-11T03:21:40Z |
en |
dc.date.issued |
2019-06 |
en |
dc.identifier.issn |
0268-0033 |
en |
dc.identifier.uri |
http://hdl.handle.net/2292/40881 |
en |
dc.description.abstract |
The lung is a delicately balanced and highly integrated mechanical system. Lung tissue is continuously exposed to the environment via the air we breathe, making it susceptible to damage. As a consequence, respiratory diseases present a huge burden on society and their prevalence continues to rise. Emergent function is produced not only by the sum of the function of its individual components but also by the complex feedback and interactions occurring across the biological scales - from genes to proteins, cells, tissue and whole organ - and back again. Computational modeling provides the necessary framework for pulling apart and putting back together the pieces of the body and organ systems so that we can fully understand how they function in both health and disease. In this review, we discuss models of lung tissue mechanics spanning from the protein level (the extracellular matrix) through to the level of cells, tissue and whole organ, many of which have been developed in isolation. This is a vital step in the process but to understand the emergent behavior of the lung, we must work towards integrating these component parts and accounting for feedback across the scales, such as mechanotransduction. These interactions will be key to unlocking the mechanisms occurring in disease and in seeking new pharmacological targets and improving personalized healthcare. |
en |
dc.format.medium |
Print-Electronic |
en |
dc.language |
eng |
en |
dc.relation.ispartofseries |
Clinical biomechanics (Bristol, Avon) |
en |
dc.rights |
Items in ResearchSpace are protected by copyright, with all rights reserved, unless otherwise indicated. Previously published items are made available in accordance with the copyright policy of the publisher. |
en |
dc.rights.uri |
https://researchspace.auckland.ac.nz/docs/uoa-docs/rights.htm |
en |
dc.subject |
Lung |
en |
dc.subject |
Pulmonary Alveoli |
en |
dc.subject |
Extracellular Matrix |
en |
dc.subject |
Humans |
en |
dc.subject |
Pulmonary Fibrosis |
en |
dc.subject |
Disease Progression |
en |
dc.subject |
Collagen |
en |
dc.subject |
Elastin |
en |
dc.subject |
Proteoglycans |
en |
dc.subject |
Mechanotransduction, Cellular |
en |
dc.subject |
Models, Biological |
en |
dc.subject |
Computer Simulation |
en |
dc.title |
Integrated lung tissue mechanics one piece at a time: Computational modeling across the scales of biology. |
en |
dc.type |
Journal Article |
en |
dc.identifier.doi |
10.1016/j.clinbiomech.2018.01.002 |
en |
pubs.begin-page |
20 |
en |
pubs.volume |
66 |
en |
dc.rights.holder |
Copyright: The author |
en |
dc.identifier.pmid |
29352607 |
en |
pubs.end-page |
31 |
en |
pubs.publication-status |
Published |
en |
dc.rights.accessrights |
http://purl.org/eprint/accessRights/RestrictedAccess |
en |
pubs.subtype |
Research Support, Non-U.S. Gov't |
en |
pubs.subtype |
Review |
en |
pubs.subtype |
Journal Article |
en |
pubs.subtype |
Research Support, N.I.H., Extramural |
en |
pubs.elements-id |
722449 |
en |
pubs.org-id |
Bioengineering Institute |
en |
pubs.org-id |
ABI Associates |
en |
dc.identifier.eissn |
1879-1271 |
en |
pubs.record-created-at-source-date |
2018-01-21 |
en |
pubs.dimensions-id |
29352607 |
en |