Integrated lung tissue mechanics one piece at a time: Computational modeling across the scales of biology.

Show simple item record Burrowes, Kelly en Iravani, Amin en Kang, Wenying en 2018-10-11T03:21:40Z en 2019-06 en
dc.identifier.issn 0268-0033 en
dc.identifier.uri en
dc.description.abstract The lung is a delicately balanced and highly integrated mechanical system. Lung tissue is continuously exposed to the environment via the air we breathe, making it susceptible to damage. As a consequence, respiratory diseases present a huge burden on society and their prevalence continues to rise. Emergent function is produced not only by the sum of the function of its individual components but also by the complex feedback and interactions occurring across the biological scales - from genes to proteins, cells, tissue and whole organ - and back again. Computational modeling provides the necessary framework for pulling apart and putting back together the pieces of the body and organ systems so that we can fully understand how they function in both health and disease. In this review, we discuss models of lung tissue mechanics spanning from the protein level (the extracellular matrix) through to the level of cells, tissue and whole organ, many of which have been developed in isolation. This is a vital step in the process but to understand the emergent behavior of the lung, we must work towards integrating these component parts and accounting for feedback across the scales, such as mechanotransduction. These interactions will be key to unlocking the mechanisms occurring in disease and in seeking new pharmacological targets and improving personalized healthcare. en
dc.format.medium Print-Electronic en
dc.language eng en
dc.relation.ispartofseries Clinical biomechanics (Bristol, Avon) en
dc.rights Items in ResearchSpace are protected by copyright, with all rights reserved, unless otherwise indicated. Previously published items are made available in accordance with the copyright policy of the publisher. en
dc.rights.uri en
dc.subject Lung en
dc.subject Pulmonary Alveoli en
dc.subject Extracellular Matrix en
dc.subject Humans en
dc.subject Pulmonary Fibrosis en
dc.subject Disease Progression en
dc.subject Collagen en
dc.subject Elastin en
dc.subject Proteoglycans en
dc.subject Mechanotransduction, Cellular en
dc.subject Models, Biological en
dc.subject Computer Simulation en
dc.title Integrated lung tissue mechanics one piece at a time: Computational modeling across the scales of biology. en
dc.type Journal Article en
dc.identifier.doi 10.1016/j.clinbiomech.2018.01.002 en
pubs.begin-page 20 en
pubs.volume 66 en
dc.rights.holder Copyright: The author en
dc.identifier.pmid 29352607 en
pubs.end-page 31 en
pubs.publication-status Published en
dc.rights.accessrights en
pubs.subtype Research Support, Non-U.S. Gov't en
pubs.subtype Review en
pubs.subtype Journal Article en
pubs.subtype Research Support, N.I.H., Extramural en
pubs.elements-id 722449 en Bioengineering Institute en ABI Associates en
dc.identifier.eissn 1879-1271 en
pubs.record-created-at-source-date 2018-01-21 en
pubs.dimensions-id 29352607 en

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