The reduction in circulating levels of melatonin may be associated with the development of preeclampsia.

Show simple item record Zeng, K en Gao, Y en Wan, J en Tong, M en Lee, Arier en Zhao, M en Chen, Qi en 2018-10-14T22:55:46Z en 2016-11 en
dc.identifier.issn 0950-9240 en
dc.identifier.uri en
dc.description.abstract Placental dysfunction and oxidative stress contribute to the pathogenesis of preeclampsia, which is a pregnancy-specific disorder. It has been suggested that the incidence of preeclampsia has a seasonal variation. Melatonin, as a seasonal factor, has been suggested to be involved in a successful pregnancy. In this study, we investigated the association of circulating levels of melatonin with preeclampsia. Serum was collected from women with preeclampsia (n=113) and gestation-matched healthy pregnant women, and the levels of melatonin were measured. In addition, the expression of melatonin receptors was examined in preeclamptic placentae (n=27). The association of the incidence of preeclampsia and seasonal variation was also analysed from 1491 women with preeclampsia within 77 745 healthy pregnancies. The serum levels of melatonin were significantly reduced in women with preeclampsia at presentation and these reduced serum levels of melatonin were not associated with the severity or time onset of preeclampsia nor with seasonal variation. The expression of melatonin receptor, MT1 was reduced in preeclamptic placentae. The incidence of preeclampsia was did exhibit seasonal variation, but this was largely due to the increase in the incidence of mild or late-onset preeclampsia. Our results demonstrate that reduced melatonin levels are associated with the development of preeclampsia but that the circulating levels of melatonin do not appear to be subject to seasonal variation during pregnancy. en
dc.format.medium Print-Electronic en
dc.language eng en
dc.relation.ispartofseries Journal of human hypertension en
dc.rights Items in ResearchSpace are protected by copyright, with all rights reserved, unless otherwise indicated. Previously published items are made available in accordance with the copyright policy of the publisher. en
dc.rights.uri en
dc.subject Placenta en
dc.subject Humans en
dc.subject Pre-Eclampsia en
dc.subject Melatonin en
dc.subject Receptor, Melatonin, MT1 en
dc.subject Incidence en
dc.subject Risk Factors en
dc.subject Retrospective Studies en
dc.subject Seasons en
dc.subject Down-Regulation en
dc.subject Pregnancy en
dc.subject Hospitals, Teaching en
dc.subject China en
dc.subject Female en
dc.subject Biomarkers en
dc.title The reduction in circulating levels of melatonin may be associated with the development of preeclampsia. en
dc.type Journal Article en
dc.identifier.doi 10.1038/jhh.2016.37 en
pubs.issue 11 en
pubs.begin-page 666 en
pubs.volume 30 en
dc.rights.holder Copyright: The author en
dc.identifier.pmid 27251079 en
pubs.end-page 671 en
pubs.publication-status Published en
dc.rights.accessrights en
pubs.subtype Research Support, Non-U.S. Gov't en
pubs.subtype Journal Article en
pubs.elements-id 546533 en Medical and Health Sciences en Population Health en Epidemiology & Biostatistics en School of Medicine en Obstetrics and Gynaecology en
dc.identifier.eissn 1476-5527 en
pubs.record-created-at-source-date 2016-06-03 en
pubs.dimensions-id 27251079 en

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