Maternally Administered Cyclic Glycine-Proline Increases Insulin-Like Growth Factor-1 Bioavailability and Novelty Recognition in Developing Offspring.

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dc.contributor.author Singh-Mallah, Gagandeep en
dc.contributor.author Singh, Kuljeet en
dc.contributor.author McMahon, Christopher D en
dc.contributor.author Harris, Paul en
dc.contributor.author Brimble, Margaret en
dc.contributor.author Thorstensen, Eric en
dc.contributor.author Guan, Jian en
dc.date.accessioned 2018-10-14T23:31:53Z en
dc.date.issued 2016-08 en
dc.identifier.issn 0013-7227 en
dc.identifier.uri http://hdl.handle.net/2292/41443 en
dc.description.abstract Cyclic glycine-proline (cGP), a metabolite of IGF-1, is an endogenous neuropeptide that improves memory in adult rats. The presence and concentrations of endogenous cGP, and its association with IGF-1 and IGF binding protein-3 (IGFBP-3) in rat milk and plasma, were evaluated during postnatal development. Maternal-infantile transfer of cGP during lactation and its efficacy on the memory of developing offspring were also investigated. Dams were gavaged with either cGP (3 mg/kg) or saline daily from postnatal days 8-22. Concentrations of cGP were measured in dams' milk, and concentrations of cGP, IGF-1, and IGFBP-3 were measured in the plasma of dams, pups, and young adults. The recognition memory, locomotor function, and anxiety-like behavior of offspring were evaluated using behavioral tests. Endogenous cGP was detected in rat milk, and its concentration was higher during peak lactation compared with late lactation. Comparisons within control groups showed low endogenous IGF-1 and IGFBP-3 and high endogenous cGP concentrations in the plasma of male pups. The reduced IGFBP-3 and increased cGP may be a response to increase the bioavailability of IGF-1 during infancy. Exogenous cGP showed oral bioavailability and effective maternal-infantile transfer through milk. Maternally transferred cGP also led to improved recognition memory in the developing offspring, possibly through increased IGF-1 bioavailability, with no effect on locomotor activity and anxiety-like behavior. These results show that cGP is an essential endogenous peptide during early postnatal development as it improves the bioavailability of IGF-1 during infancy. Furthermore, maternal cGP supplementation offers an effective and natural route of administration for improving memory in the developing offspring. en
dc.format.medium Print-Electronic en
dc.language eng en
dc.relation.ispartofseries Endocrinology en
dc.rights Items in ResearchSpace are protected by copyright, with all rights reserved, unless otherwise indicated. Previously published items are made available in accordance with the copyright policy of the publisher. en
dc.rights.uri https://researchspace.auckland.ac.nz/docs/uoa-docs/rights.htm en
dc.subject Animals en
dc.subject Rats en
dc.subject Rats, Sprague-Dawley en
dc.subject Prenatal Exposure Delayed Effects en
dc.subject Peptides, Cyclic en
dc.subject Proline en
dc.subject Glycine en
dc.subject Insulin-Like Growth Factor I en
dc.subject Exploratory Behavior en
dc.subject Recognition (Psychology) en
dc.subject Biological Availability en
dc.subject Pregnancy en
dc.subject Female en
dc.subject Male en
dc.subject Maternal Nutritional Physiological Phenomena en
dc.title Maternally Administered Cyclic Glycine-Proline Increases Insulin-Like Growth Factor-1 Bioavailability and Novelty Recognition in Developing Offspring. en
dc.type Journal Article en
dc.identifier.doi 10.1210/en.2016-1189 en
pubs.issue 8 en
pubs.begin-page 3130 en
pubs.volume 157 en
dc.rights.holder Copyright: The author en
dc.identifier.pmid 27355491 en
pubs.end-page 3139 en
pubs.publication-status Published en
dc.rights.accessrights http://purl.org/eprint/accessRights/RestrictedAccess en
pubs.subtype Research Support, Non-U.S. Gov't en
pubs.subtype Journal Article en
pubs.elements-id 538097 en
pubs.org-id Medical and Health Sciences en
pubs.org-id Medical Sciences en
pubs.org-id Pharmacology en
pubs.org-id Science en
pubs.org-id Biological Sciences en
pubs.org-id Chemistry en
pubs.org-id Science Research en
pubs.org-id Maurice Wilkins Centre (2010-2014) en
dc.identifier.eissn 1945-7170 en
pubs.record-created-at-source-date 2016-06-30 en
pubs.dimensions-id 27355491 en


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