Modelling the effects of calcium waves and oscillations on saliva secretion.

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Show simple item record Palk, Laurence en Sneyd, A en Patterson, Kate en Shuttleworth, Trevor J en Yule, David I en MacLaren, Oliver en Crampin, Edmund en 2018-10-15T01:08:46Z en 2012-07 en
dc.identifier.issn 0022-5193 en
dc.identifier.uri en
dc.description.abstract An understanding of Ca(2+) signalling in saliva-secreting acinar cells is important, as Ca(2+) is the second messenger linking stimulation of cells to production of saliva. Ca(2+) signals affect secretion via the ion channels located both apically and basolaterally in the cell. By approximating Ca(2+) waves with periodic functions on the apical and basolateral membranes, we isolate individual wave properties and investigate them for their effect on fluid secretion in a mathematical model of the acinar cell. Mean Ca(2+) concentration is found to be the most significant property in signalling secretion. Wave speed was found to encode a range of secretion rates. Ca(2+) oscillation frequency and amplitude had little effect on fluid secretion. en
dc.format.medium Print-Electronic en
dc.language eng en
dc.relation.ispartofseries Journal of theoretical biology en
dc.rights Items in ResearchSpace are protected by copyright, with all rights reserved, unless otherwise indicated. Previously published items are made available in accordance with the copyright policy of the publisher. en
dc.rights.uri en
dc.subject Saliva en
dc.subject Humans en
dc.subject Chloride Channels en
dc.subject Ion Channel Gating en
dc.subject Calcium Signaling en
dc.subject Secretory Rate en
dc.subject Salivation en
dc.subject Models, Biological en
dc.subject Acinar Cells en
dc.title Modelling the effects of calcium waves and oscillations on saliva secretion. en
dc.type Journal Article en
dc.identifier.doi 10.1016/j.jtbi.2012.04.009 en
pubs.begin-page 45 en
pubs.volume 305 en
dc.rights.holder Copyright: Elsevier Ltd. en
dc.identifier.pmid 22521411 en
pubs.end-page 53 en
pubs.publication-status Published en
dc.rights.accessrights en
pubs.subtype research-article en
pubs.subtype Journal Article en
pubs.subtype Research Support, N.I.H., Extramural en
pubs.elements-id 344780 en Bioengineering Institute en ABI Associates en Engineering en Engineering Science en Science en Mathematics en Science Research en Maurice Wilkins Centre (2010-2014) en
dc.identifier.eissn 1095-8541 en
pubs.record-created-at-source-date 2012-05-28 en
pubs.dimensions-id 22521411 en

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