Modelling the effects of calcium waves and oscillations on saliva secretion.

Abstract

An understanding of Ca(2+) signalling in saliva-secreting acinar cells is important, as Ca(2+) is the second messenger linking stimulation of cells to production of saliva. Ca(2+) signals affect secretion via the ion channels located both apically and basolaterally in the cell. By approximating Ca(2+) waves with periodic functions on the apical and basolateral membranes, we isolate individual wave properties and investigate them for their effect on fluid secretion in a mathematical model of the acinar cell. Mean Ca(2+) concentration is found to be the most significant property in signalling secretion. Wave speed was found to encode a range of secretion rates. Ca(2+) oscillation frequency and amplitude had little effect on fluid secretion.