The effect of high dose rate brachytherapy in combination with external beam radiotherapy on men's health-related quality of life and sexual function over a 2 year time span.

Show simple item record Conaglen, Helen en de Jong, D en Hartopeanu, C en Conaglen, John en Tyrie, LK en 2018-10-15T01:27:58Z en 2013-03 en
dc.identifier.issn 0936-6555 en
dc.identifier.uri en
dc.description.abstract AIM: To investigate changes in health-related quality of life and sexual function in men after high dose rate (HDR) brachytherapy and external beam radiotherapy (EBRT), with or without androgen deprivation therapy, for localised prostate cancer. MATERIALS AND METHODS: Eligible men who had undergone HDR brachytherapy/EBRT for their prostate cancer completed questionnaires before any treatment (baseline) and at 3 monthly intervals. The European Organization for Research and Treatment of Cancer (EORTC) C30 quality of life measure (QLQ-C30), the PR25 prostate-specific supplement and the International Index of Erectile Function-Short Form (IIEF-SF) were completed. An analysis of changes from baseline to 2 years, for the 87 men who completed surveys, was carried out. RESULTS: The mean EORTC QLQ-C30 quality of life scores, urinary, bowel and sexual symptoms had all improved. However, improvements did not return men to baseline levels at 2 years. Sexual function as measured by both scales was least likely to recover. There were no differences due to androgen deprivation therapy. Minimally important differences were still reported by men at 2 years as follows: urinary (36%), bowel (24%), hormone treatment side-effects (40%), IIEF-SF (55%). Discrepancies between mean and minimally important differences changes are explained by some men remaining more affected by their therapy than others. CONCLUSION: The findings do not support our first hypothesis that urinary, bowel and sexual problems in these men will return to baseline levels once therapy is completed and 2 years have elapsed. Our findings indicate the changes men experience are significant, do occur early, and many do not resolve in the longer term. en
dc.format.medium Print-Electronic en
dc.language eng en
dc.relation.ispartofseries Clinical oncology (Royal College of Radiologists (Great Britain)) en
dc.rights Items in ResearchSpace are protected by copyright, with all rights reserved, unless otherwise indicated. Previously published items are made available in accordance with the copyright policy of the publisher. en
dc.rights.uri en
dc.subject Humans en
dc.subject Prostatic Neoplasms en
dc.subject Antineoplastic Agents, Hormonal en
dc.subject Brachytherapy en
dc.subject Radiotherapy Dosage en
dc.subject Radiotherapy Planning, Computer-Assisted en
dc.subject Questionnaires en
dc.subject Sexual Behavior en
dc.subject Quality of Life en
dc.subject Aged en
dc.subject Aged, 80 and over en
dc.subject Middle Aged en
dc.subject Male en
dc.subject Sexual Dysfunction, Physiological en
dc.title The effect of high dose rate brachytherapy in combination with external beam radiotherapy on men's health-related quality of life and sexual function over a 2 year time span. en
dc.type Journal Article en
dc.identifier.doi 10.1016/j.clon.2012.10.012 en
pubs.issue 3 en
pubs.begin-page 197 en
pubs.volume 25 en
dc.rights.holder Copyright: The author en
dc.identifier.pmid 23183305 en
pubs.end-page 204 en
pubs.publication-status Published en
dc.rights.accessrights en
pubs.subtype Journal Article en
pubs.elements-id 368805 en Medical and Health Sciences en School of Medicine en Medicine Department en
dc.identifier.eissn 1433-2981 en
pubs.record-created-at-source-date 2013-02-04 en
pubs.dimensions-id 23183305 en

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