dc.contributor.author |
Hall, Christopher |
en |
dc.contributor.author |
Boyle, Rachel H |
en |
dc.contributor.author |
Sun, Xueying |
en |
dc.contributor.author |
Wicker, Sophie M |
en |
dc.contributor.author |
Misa, June P |
en |
dc.contributor.author |
Krissansen, Geoffrey |
en |
dc.contributor.author |
Print, Cristin |
en |
dc.contributor.author |
Crosier, Kathryn |
en |
dc.contributor.author |
Crosier, Philip |
en |
dc.date.accessioned |
2018-10-15T02:14:13Z |
en |
dc.date.issued |
2014-01 |
en |
dc.identifier.issn |
2041-1723 |
en |
dc.identifier.uri |
http://hdl.handle.net/2292/41538 |
en |
dc.description.abstract |
In addition to satisfying the metabolic demands of cells, mitochondrial metabolism helps regulate immune cell function. To date, such cell-intrinsic metabolic-immunologic cross-talk has only been described operating in cells of the immune system. Here we show that epidermal cells utilize fatty acid β-oxidation to fuel their contribution to the immune response during cutaneous inflammation. By live imaging metabolic and immunological processes within intact zebrafish embryos during cutaneous inflammation, we uncover a mechanism where elevated β-oxidation-fuelled mitochondria-derived reactive oxygen species within epidermal cells helps guide matrix metalloproteinase-driven leukocyte recruitment. This mechanism requires the activity of a zebrafish homologue of the mammalian mitochondrial enzyme, Immunoresponsive gene 1. This study describes the first example of metabolic reprogramming operating within a non-immune cell type to help control its contribution to the immune response. Targeting of this metabolic-immunologic interface within keratinocytes may prove useful in treating inflammatory dermatoses. |
en |
dc.format.medium |
Electronic |
en |
dc.language |
eng |
en |
dc.relation.ispartofseries |
Nature communications |
en |
dc.rights |
Items in ResearchSpace are protected by copyright, with all rights reserved, unless otherwise indicated. Previously published items are made available in accordance with the copyright policy of the publisher. Details obtained from http://www.sherpa.ac.uk/romeo/issn/2041-1723/ |
en |
dc.rights.uri |
https://researchspace.auckland.ac.nz/docs/uoa-docs/rights.htm |
en |
dc.subject |
Epidermis |
en |
dc.subject |
Leukocytes |
en |
dc.subject |
Mitochondria |
en |
dc.subject |
Macrophages |
en |
dc.subject |
Animals |
en |
dc.subject |
Zebrafish |
en |
dc.subject |
Mice |
en |
dc.subject |
Salmonella Infections, Animal |
en |
dc.subject |
Dermatitis, Atopic |
en |
dc.subject |
Disease Models, Animal |
en |
dc.subject |
Inflammation |
en |
dc.subject |
Reactive Oxygen Species |
en |
dc.subject |
Fatty Acids |
en |
dc.subject |
Zebrafish Proteins |
en |
dc.subject |
Receptors, Glucocorticoid |
en |
dc.subject |
RNA, Messenger |
en |
dc.subject |
Glucocorticoids |
en |
dc.subject |
Survival Analysis |
en |
dc.subject |
Gene Expression Profiling |
en |
dc.subject |
Signal Transduction |
en |
dc.subject |
Cell Movement |
en |
dc.subject |
Neutrophil Infiltration |
en |
dc.subject |
Oxidation-Reduction |
en |
dc.subject |
Larva |
en |
dc.subject |
Matrix Metalloproteinase 9 |
en |
dc.subject |
Morpholinos |
en |
dc.title |
Epidermal cells help coordinate leukocyte migration during inflammation through fatty acid-fuelled matrix metalloproteinase production. |
en |
dc.type |
Journal Article |
en |
dc.identifier.doi |
10.1038/ncomms4880 |
en |
pubs.begin-page |
3880 |
en |
pubs.volume |
5 |
en |
dc.rights.holder |
Copyright: Macmillan Publishers Limited |
en |
dc.identifier.pmid |
24852213 |
en |
pubs.publication-status |
Published |
en |
dc.rights.accessrights |
http://purl.org/eprint/accessRights/OpenAccess |
en |
pubs.subtype |
Research Support, Non-U.S. Gov't |
en |
pubs.subtype |
Journal Article |
en |
pubs.elements-id |
439821 |
en |
pubs.org-id |
Medical and Health Sciences |
en |
pubs.org-id |
Medical Sciences |
en |
pubs.org-id |
Molecular Medicine |
en |
pubs.org-id |
Science |
en |
pubs.org-id |
Science Research |
en |
pubs.org-id |
Maurice Wilkins Centre (2010-2014) |
en |
dc.identifier.eissn |
2041-1723 |
en |
pubs.record-created-at-source-date |
2014-05-23 |
en |
pubs.dimensions-id |
24852213 |
en |