dc.contributor.author |
Hall, Christopher |
en |
dc.contributor.author |
Crosier, Philip |
en |
dc.contributor.author |
Crosier, Kathryn |
en |
dc.date.accessioned |
2018-10-15T02:16:18Z |
en |
dc.date.issued |
2016-01 |
en |
dc.identifier.issn |
0161-5890 |
en |
dc.identifier.uri |
http://hdl.handle.net/2292/41544 |
en |
dc.description.abstract |
Hematopoietic stem cells (HSCs) are rare, largely dormant, long-lived cells that are capable of establishing and regenerating all mature blood cell lineages throughout the life of the host. Given their therapeutic importance, understanding factors that regulate HSC development and influence HSC proliferation and differentiation is of great interest. Exploring HSC biology through the lens of infection has altered our traditional view of the HSC. The HSC can now be considered a component of the immune response to infection. In response to inflammatory cytokine signaling, HSCs enhance their proliferative state and contribute to the production of in-demand blood cell lineages. Similar cytokine signaling pathways also participate during embryonic HSC production. With its highly conserved hematopoietic system and experimental tractability, the zebrafish model has made significant contributions to the hematopoietic field. In particular, the zebrafish system has been ideally suited to help reveal the molecular and cellular mechanisms underlying HSC development. This review highlights recent zebrafish studies that have uncovered new mechanistic insights into how inflammatory signaling pathways influence HSC behavior during infection and HSC production within the embryo. |
en |
dc.format.medium |
Print-Electronic |
en |
dc.language |
eng |
en |
dc.relation.ispartofseries |
Molecular immunology |
en |
dc.rights |
Items in ResearchSpace are protected by copyright, with all rights reserved, unless otherwise indicated. Previously published items are made available in accordance with the copyright policy of the publisher. |
en |
dc.rights.uri |
https://researchspace.auckland.ac.nz/docs/uoa-docs/rights.htm |
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dc.subject |
Hematopoietic Stem Cells |
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dc.subject |
Animals |
en |
dc.subject |
Zebrafish |
en |
dc.subject |
Infection |
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dc.subject |
Inflammation |
en |
dc.subject |
Cytokines |
en |
dc.subject |
Hematopoiesis |
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dc.title |
Inflammatory cytokines provide both infection-responsive and developmental signals for blood development: Lessons from the zebrafish. |
en |
dc.type |
Journal Article |
en |
dc.identifier.doi |
10.1016/j.molimm.2015.10.020 |
en |
pubs.begin-page |
113 |
en |
pubs.volume |
69 |
en |
dc.rights.holder |
Copyright: The author |
en |
dc.identifier.pmid |
26563946 |
en |
pubs.end-page |
122 |
en |
pubs.publication-status |
Published |
en |
dc.rights.accessrights |
http://purl.org/eprint/accessRights/RestrictedAccess |
en |
pubs.subtype |
Research Support, Non-U.S. Gov't |
en |
pubs.subtype |
Review |
en |
pubs.subtype |
Journal Article |
en |
pubs.elements-id |
506787 |
en |
pubs.org-id |
Medical and Health Sciences |
en |
pubs.org-id |
Medical Sciences |
en |
pubs.org-id |
Molecular Medicine |
en |
pubs.org-id |
Science |
en |
pubs.org-id |
Science Research |
en |
pubs.org-id |
Maurice Wilkins Centre (2010-2014) |
en |
dc.identifier.eissn |
1872-9142 |
en |
pubs.record-created-at-source-date |
2016-01-02 |
en |
pubs.dimensions-id |
26563946 |
en |