A statistical shape model of the thumb carpometacarpal joint

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dc.contributor.author Schneider, Marco en
dc.contributor.author Crisco, JJT en
dc.contributor.author Weiss, AC en
dc.contributor.author Ladd, AL en
dc.contributor.author Nielsen, Poul en
dc.contributor.author Besier, Thor en
dc.contributor.author Zhang, Ju en
dc.coverage.spatial Newport, Rhode Island en
dc.date.accessioned 2018-10-15T02:20:47Z en
dc.date.issued 2013 en
dc.identifier.uri http://hdl.handle.net/2292/41552 en
dc.description.abstract INTRODUCTION. The first carpometacarpal (CMC) joint performs a range of dexterous movements, all of which are influenced by the morphology and articulation between the first metacarpal and trapezium bones. However, the CMC joint is highly susceptible to osteoarthritis, which is more prevalent with age and 5-7 times more prevalent in women than in men. Here we present a statistical shape model of the CMC joint to investigate age and sex differences in CMC joint morphology. METHODS. A training set of 50 CMC joints were manually segmented from CT images of the hand with a resolution of 0.4x0.4x0.625mm (age range: 18 yrs to 67 yrs; 24 females and 26 males). A template mesh consisting of parametric surface elements was created for a single segmentation and then fitted to the entire training set (n=50), resulting in a set of correspondent meshes of the metacarpal and trapezium. Principal Component Analysis was performed on these meshes to determine significant modes of shape variation. We then performed linear regression and one-way ANOVA on the mode scores of the meshes against age and sex. RESULTS. Over 95% of CMC joint morphological variation was described to an accuracy of ~0.2 mm RMS by the first seven modes of the shape model. None of the modes showed significant correlation with age. However, there was a very strong correlation between sex and the 1st mode, which described the size of the CMC joint (Figure 1, p <0.001). The male CMC joints tended to have negative coefficients for the 1st mode, indicating larger size, compared to the females, who had positive coefficients (Figure 2). DISCUSSION. We have developed a statistical shape model, which accurately described the morphology of the CMC joint. Age did not appear to influence the shape of the CMC joint, nor did sex, with the exception of the first mode, which accounted for overall size of the joint. We will use this shape model to develop an active shape model to automatically segment clinical CT images, which will enable us to investigate a larger cohort and support these findings. Although we did not see much variation in shape between male and female CMC joints, size alone might explain the increased incidence of CMC osteoarthritis, given that a smaller CMC joint will also have a smaller contact area and experience greater cartilage stress for a given force. Further work to investigate the articulating surface and corresponding joint mechanics is required. Acknowledgements. We would like to thank the Auckland Bioengineering Institute, Stanford Orthopaedics, and the NIH for funding. COI. No conflicts of interests. en
dc.description.uri https://www.brown.edu/academics/medical/about/departments/orthopaedics/bioengineering/sites/brown.edu.academics.medical.about.departments.orthopaedics.bioengineering/files/uploads/ITOW%202013%20Abstract%20Book.pdf en
dc.relation.ispartof 1st International Thumb Osteoarthritis Workshop en
dc.rights Items in ResearchSpace are protected by copyright, with all rights reserved, unless otherwise indicated. Previously published items are made available in accordance with the copyright policy of the publisher. en
dc.rights.uri https://researchspace.auckland.ac.nz/docs/uoa-docs/rights.htm en
dc.title A statistical shape model of the thumb carpometacarpal joint en
dc.type Presentation en
pubs.begin-page 16 en
dc.rights.holder Copyright: The author en
pubs.author-url https://www.brown.edu/academics/medical/about/departments/orthopaedics/bioengineering/sites/brown.edu.academics.medical.about.departments.orthopaedics.bioengineering/files/uploads/ITOW%202013%20Abstract%20Book.pdf en
pubs.end-page 16 en
pubs.finish-date 2013-10-26 en
pubs.place-of-publication Newport en
pubs.start-date 2013-10-25 en
dc.rights.accessrights http://purl.org/eprint/accessRights/RestrictedAccess en
pubs.subtype Conference Oral Presentation en
pubs.elements-id 418215 en
pubs.org-id Bioengineering Institute en
pubs.org-id ABI Associates en
pubs.org-id Engineering en
pubs.org-id Engineering Science en
pubs.org-id Science en
pubs.org-id Science Research en
pubs.org-id Maurice Wilkins Centre (2010-2014) en
pubs.record-created-at-source-date 2013-12-13 en

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