Integrated scientific data bases review on asulacrine and associated toxicity.

Show simple item record Afzal, Attia en Sarfraz, Muhammad en Wu, Zimei en Wang, Guangji en Sun, Jianguo en 2018-10-15T02:46:16Z en 2016-08 en
dc.identifier.issn 1879-0461 en
dc.identifier.uri en
dc.description.abstract Asulacrine (ASL), a weakly basic and highly lipophilic drug was synthesized in 1980's in cancer research laboratory of Auckland by modifications to the acridine portion of amsacrine on 3-, 4- and 5-substitution patterns. In contrast to its precursor amsacrine (m-AMSA), ASL was effective not only against leukemia and Lewis lung tumor system but also a wide variety of solid tumor. Its metabolic pathway is not same to amsacrine hence different side effects, hepatotoxicity and excretion was observed. Asulacrine is under phase II clinical trials and has showed promising results but its toxicity especially phlebitis is stumbling block in its clinical implementation. This review is an effort to give a possible clue, based on scientifically proven results, to the researchers to solve the mystery of associated toxicity, phlebitis. Review covers the available literature on asulacrine and other acridine derivatives regarding pharmacology, pharmacokinetics, quantitative structure activity relationship and toxicology via electronic search using scientific databases like PubMed and others. To date, all abstracts and full-text articles were discussed and analyzed. The tabulated comparisons and circuitry mechanism of ASL are the added features of the review which give a complete understanding of hidden aspects of possible route cause of associated toxicity, the phlebitis. en
dc.format.medium Print-Electronic en
dc.language eng en
dc.relation.ispartofseries Critical reviews in oncology/hematology en
dc.rights Items in ResearchSpace are protected by copyright, with all rights reserved, unless otherwise indicated. Previously published items are made available in accordance with the copyright policy of the publisher. en
dc.rights.uri en
dc.subject Animals en
dc.subject Humans en
dc.subject Neoplasms en
dc.subject Amsacrine en
dc.subject Antineoplastic Agents en
dc.subject Signal Transduction en
dc.subject Oxidative Stress en
dc.title Integrated scientific data bases review on asulacrine and associated toxicity. en
dc.type Journal Article en
dc.identifier.doi 10.1016/j.critrevonc.2016.05.013 en
pubs.begin-page 78 en
pubs.volume 104 en
dc.rights.holder Copyright: The author en
dc.identifier.pmid 27321375 en
pubs.end-page 86 en
pubs.publication-status Published en
dc.rights.accessrights en
pubs.subtype Review en
pubs.subtype Journal Article en
pubs.elements-id 531426 en Medical and Health Sciences en Pharmacy en
dc.identifier.eissn 1879-0461 en
pubs.record-created-at-source-date 2016-07-12 en
pubs.dimensions-id 27321375 en

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