dc.contributor.author |
Terem, Itamar |
en |
dc.contributor.author |
Ni, Wendy W |
en |
dc.contributor.author |
Goubran, Maged |
en |
dc.contributor.author |
Rahimi, Mahdi Salmani |
en |
dc.contributor.author |
Zaharchuk, Greg |
en |
dc.contributor.author |
Yeom, Kristen W |
en |
dc.contributor.author |
Moseley, Michael E |
en |
dc.contributor.author |
Kurt, Mehmet |
en |
dc.contributor.author |
Holdsworth, Samantha |
en |
dc.date.accessioned |
2018-10-15T02:46:31Z |
en |
dc.date.issued |
2018-12 |
en |
dc.identifier.issn |
0740-3194 |
en |
dc.identifier.uri |
http://hdl.handle.net/2292/41615 |
en |
dc.description.abstract |
PURPOSE:Amplified magnetic resonance imaging (aMRI) was recently introduced as a new brain motion detection and visualization method. The original aMRI approach used a video-processing algorithm, Eulerian video magnification (EVM), to amplify cardio-ballistic motion in retrospectively cardiac-gated MRI data. Here, we strive to improve aMRI by incorporating a phase-based motion amplification algorithm. METHODS:Phase-based aMRI was developed and tested for correct implementation and ability to amplify sub-voxel motions using digital phantom simulations. The image quality of phase-based aMRI was compared with EVM-based aMRI in healthy volunteers at 3T, and its amplified motion characteristics were compared with phase-contrast MRI. Data were also acquired on a patient with Chiari I malformation, and qualitative displacement maps were produced using free form deformation (FFD) of the aMRI output. RESULTS:Phantom simulations showed that phase-based aMRI has a linear dependence of amplified displacement on true displacement. Amplification was independent of temporal frequency, varying phantom intensity, Rician noise, and partial volume effect. Phase-based aMRI supported larger amplification factors than EVM-based aMRI and was less sensitive to noise and artifacts. Abnormal biomechanics were seen on FFD maps of the Chiari I malformation patient. CONCLUSION:Phase-based aMRI might be used in the future for quantitative analysis of minute changes in brain motion and may reveal subtle physiological variations of the brain as a result of pathology using processing of the fundamental harmonic or by selectively varying temporal harmonics. Preliminary data shows the potential of phase-based aMRI to qualitatively assess abnormal biomechanics in Chiari I malformation. |
en |
dc.format.medium |
Print-Electronic |
en |
dc.language |
eng |
en |
dc.relation.ispartofseries |
Magnetic resonance in medicine |
en |
dc.rights |
Items in ResearchSpace are protected by copyright, with all rights reserved, unless otherwise indicated. Previously published items are made available in accordance with the copyright policy of the publisher. |
en |
dc.rights.uri |
https://researchspace.auckland.ac.nz/docs/uoa-docs/rights.htm |
en |
dc.subject |
Foramen Magnum |
en |
dc.subject |
Brain |
en |
dc.subject |
Humans |
en |
dc.subject |
Arnold-Chiari Malformation |
en |
dc.subject |
Cerebellar Ataxia |
en |
dc.subject |
Image Interpretation, Computer-Assisted |
en |
dc.subject |
Magnetic Resonance Imaging |
en |
dc.subject |
Phantoms, Imaging |
en |
dc.subject |
Movement |
en |
dc.subject |
Algorithms |
en |
dc.subject |
Computer Simulation |
en |
dc.subject |
Image Processing, Computer-Assisted |
en |
dc.subject |
Video Recording |
en |
dc.subject |
Adult |
en |
dc.subject |
Child, Preschool |
en |
dc.subject |
Female |
en |
dc.subject |
Male |
en |
dc.subject |
Healthy Volunteers |
en |
dc.title |
Revealing sub-voxel motions of brain tissue using phase-based amplified MRI (aMRI). |
en |
dc.type |
Journal Article |
en |
dc.identifier.doi |
10.1002/mrm.27236 |
en |
pubs.issue |
6 |
en |
pubs.begin-page |
2549 |
en |
pubs.volume |
80 |
en |
dc.rights.holder |
Copyright: The author |
en |
pubs.end-page |
2559 |
en |
pubs.publication-status |
Published |
en |
dc.rights.accessrights |
http://purl.org/eprint/accessRights/RestrictedAccess |
en |
pubs.subtype |
Research Support, Non-U.S. Gov't |
en |
pubs.subtype |
research-article |
en |
pubs.subtype |
Journal Article |
en |
pubs.subtype |
Research Support, N.I.H., Extramural |
en |
pubs.elements-id |
750345 |
en |
pubs.org-id |
Medical and Health Sciences |
en |
pubs.org-id |
Medical Sciences |
en |
pubs.org-id |
Anatomy and Medical Imaging |
en |
dc.identifier.eissn |
1522-2594 |
en |
pubs.record-created-at-source-date |
2018-05-31 |
en |
pubs.dimensions-id |
29845645 |
en |