Propensity score analysis evaluating preoperative glucocorticoid administration in elective colectomy.

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dc.contributor.author Lemanu, Daniel en
dc.contributor.author Srinivasa, Sanket en
dc.contributor.author Singh, Primal en
dc.contributor.author Kahokehr, Arman en
dc.contributor.author Zargar Shoshtari, Kamran en
dc.contributor.author Hill, Andrew en
dc.date.accessioned 2018-10-15T03:09:37Z en
dc.date.issued 2012-01 en
dc.identifier.issn 1743-9191 en
dc.identifier.uri http://hdl.handle.net/2292/41657 en
dc.description.abstract BACKGROUND: Preoperative glucocorticoid (GC) administration attenuates the physiological response to surgery and improves clinical outcomes. However, GC use is not yet universally implemented. A propensity score analysis was performed to evaluate preoperative GC use in elective colectomy. METHODS: A retrospective review of prospectively collected data was conducted for all patients who had undergone elective colectomy within an established Enhanced Recovery After Surgery (ERAS) programme at our institution from January 2006 to 2010. Demographic data, surgery type, glucocorticoid administration and clinical outcomes including complication rates and length of hospital stay (LOS) were investigated. Univariate and propensity score analyses were conducted with statistical significance identified as p ≤ 0.05. RESULTS: There were 253 patients included in the analysis, of which 146 received preoperative GC. There were significant baseline differences between those who received GC and those who did not in male gender (GC: 56 (38%); non-GC: 58 (54%); p = 0.02) and American Society of Anesthesiologists (ASA) III (GC: 40 (27%); non-GC: 43 (40%); p = 0.04). On univariate analysis, there were no significant differences in the incidence of total complications, major complication, anastomotic leak and infectious complication. On propensity score analysis, preoperative GC administration was found to be independently associated with a reduction in LOS (GC: 5; Non-GC: 6; p = 0.04). CONCLUSION: Preoperative GC administration is associated with a reduction in LOS without an increase in postoperative complications. en
dc.format.medium Print-Electronic en
dc.language eng en
dc.relation.ispartofseries International journal of surgery (London, England) en
dc.rights Items in ResearchSpace are protected by copyright, with all rights reserved, unless otherwise indicated. Previously published items are made available in accordance with the copyright policy of the publisher. en
dc.rights.uri https://researchspace.auckland.ac.nz/docs/uoa-docs/rights.htm en
dc.subject Humans en
dc.subject Inflammation en
dc.subject Glucocorticoids en
dc.subject Treatment Outcome en
dc.subject Length of Stay en
dc.subject Preoperative Care en
dc.subject Colectomy en
dc.subject Surgical Procedures, Elective en
dc.subject Analysis of Variance en
dc.subject Retrospective Studies en
dc.subject Aged en
dc.subject Aged, 80 and over en
dc.subject Middle Aged en
dc.subject Female en
dc.subject Male en
dc.subject Randomized Controlled Trials as Topic en
dc.subject Propensity Score en
dc.title Propensity score analysis evaluating preoperative glucocorticoid administration in elective colectomy. en
dc.type Journal Article en
dc.identifier.doi 10.1016/j.ijsu.2012.10.003 en
pubs.issue 10 en
pubs.begin-page 607 en
pubs.volume 10 en
dc.rights.holder Copyright: The author en
dc.identifier.pmid 23107820 en
pubs.end-page 610 en
pubs.publication-status Published en
dc.rights.accessrights http://purl.org/eprint/accessRights/RestrictedAccess en
pubs.subtype Journal Article en
pubs.elements-id 362681 en
pubs.org-id Medical and Health Sciences en
pubs.org-id School of Medicine en
pubs.org-id South Auckland clinical school en
pubs.org-id Surgery Department en
dc.identifier.eissn 1743-9159 en
pubs.record-created-at-source-date 2012-12-11 en
pubs.dimensions-id 23107820 en


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