A Parametric Computational Model of the Action Potential of Pacemaker Cells

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dc.contributor.author Ai, Weiwei en
dc.contributor.author Patel, Nitish en
dc.contributor.author Roop, Parthasarathi en
dc.contributor.author Malik, Avinash en
dc.contributor.author Andalam, S en
dc.contributor.author Yip, E en
dc.contributor.author Allen, N en
dc.contributor.author Trew, Mark en
dc.date.accessioned 2018-10-15T03:13:48Z en
dc.date.issued 2018-01 en
dc.identifier.citation IEEE Transactions on Biomedical Engineering 65(1) Jan 2017 en
dc.identifier.issn 1558-2531 en
dc.identifier.uri http://hdl.handle.net/2292/41667 en
dc.description.abstract Objective: A flexible, efficient, and verifiable pacemaker cell model is essential to the design of real-time virtual hearts that can be used for closed-loop validation of cardiac devices. A new parametric model of pacemaker action potential is developed to address this need. Methods: The action potential phases are modeled using hybrid automaton with one piecewise-linear continuous variable. The model can capture rate-dependent dynamics, such as action potential duration restitution, conduction velocity restitution, and overdrive suppression by incorporating nonlinear update functions. Simulated dynamics of the model compared well with previous models and clinical data. Conclusion: The results show that the parametric model can reproduce the electrophysiological dynamics of a variety of pacemaker cells, such as sinoatrial node, atrioventricular node, and the His-Purkinje system, under varying cardiac conditions. Significance: This is an important contribution toward closed-loop validation of cardiac devices using real-time heart models. en
dc.publisher Institute of Electrical and Electronics Engineers en
dc.relation.ispartofseries IEEE Transactions on Biomedical Engineering en
dc.rights Items in ResearchSpace are protected by copyright, with all rights reserved, unless otherwise indicated. Previously published items are made available in accordance with the copyright policy of the publisher. en
dc.rights.uri https://researchspace.auckland.ac.nz/docs/uoa-docs/rights.htm en
dc.rights.uri https://www.ieee.org/publications/rights/author-posting-policy.html en
dc.title A Parametric Computational Model of the Action Potential of Pacemaker Cells en
dc.type Journal Article en
dc.identifier.doi 10.1109/TBME.2017.2695537 en
pubs.issue 1 en
pubs.begin-page 123 en
pubs.volume 65 en
dc.rights.holder Copyright: IEEE en
pubs.end-page 130 en
dc.rights.accessrights http://purl.org/eprint/accessRights/OpenAccess en
pubs.subtype Article en
pubs.elements-id 633628 en
pubs.org-id Bioengineering Institute en
pubs.org-id ABI Associates en
pubs.org-id Engineering en
pubs.org-id Department of Electrical, Computer and Software Engineering en
pubs.number 99 en
pubs.record-created-at-source-date 2017-08-04 en
pubs.dimensions-id 28436840 en

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