The role of muscle and circulatory microRNAs as regulators and biomarkers of muscle function.

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dc.contributor.advisor Mitchell, CJ en
dc.contributor.advisor Cameron-Smith, D en
dc.contributor.author D'Souza, Randall en
dc.date.accessioned 2018-10-15T21:03:54Z en
dc.date.issued 2018 en
dc.identifier.uri http://hdl.handle.net/2292/41776 en
dc.description.abstract Skeletal muscle is an abundant tissue type with critical roles in locomotion, force production and whole body energy regulation. Skeletal muscle mass and function are adaptively regulated by multiple stimuli including physical loading (exercise), nutrient intake (protein supplementation) and lifestyle events (injury and unloading). MicroRNAs (miRNAs) are short non-coding RNAs with the capacity to target specific mRNAs for breakdown and thereby alter the rate and extent of protein expression. Therefore, miRNAs may explain often observed disconnects between gene and protein expression and may regulate key mechanisms underpinning muscle phenotype. The studies in this thesis used a targeted qRT-PCR approach to address the role of muscle regulatory miRNAs in multiple models. en
dc.publisher ResearchSpace@Auckland en
dc.relation.ispartof PhD Thesis - University of Auckland en
dc.relation.isreferencedby UoA99265085713702091 en
dc.rights Items in ResearchSpace are protected by copyright, with all rights reserved, unless otherwise indicated. Previously published items are made available in accordance with the copyright policy of the publisher. en
dc.rights.uri https://researchspace.auckland.ac.nz/docs/uoa-docs/rights.htm en
dc.rights.uri http://creativecommons.org/licenses/by-nc-sa/3.0/nz/ en
dc.title The role of muscle and circulatory microRNAs as regulators and biomarkers of muscle function. en
dc.type Thesis en
thesis.degree.discipline Biomedical Science en
thesis.degree.grantor The University of Auckland en
thesis.degree.level Doctoral en
thesis.degree.name PhD en
dc.rights.holder Copyright: The author en
dc.rights.accessrights http://purl.org/eprint/accessRights/OpenAccess en
pubs.elements-id 754852 en
pubs.org-id Medical and Health Sciences en
pubs.org-id Medical Sciences en
pubs.org-id Nutrition en
pubs.record-created-at-source-date 2018-10-16 en


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http://creativecommons.org/licenses/by-nc-sa/3.0/nz/ Except where otherwise noted, this item's license is described as http://creativecommons.org/licenses/by-nc-sa/3.0/nz/

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